Cargando…

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malik, Manasi, Parikh, Ishita, Vasquez, Jared B., Smith, Conor, Tai, Leon, Bu, Guojun, LaDu, Mary Jo, Fardo, David W., Rebeck, G. William, Estus, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595327/ https://www.ncbi.nlm.nih.gov/pubmed/26438529 http://dx.doi.org/10.1186/s13024-015-0048-1

Ejemplares similares

Genetics of PICALM Expression and Alzheimer's Disease
por: Parikh, Ishita, et al.
Publicado: (2014)

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
por: Tai, Leon M, et al.
Publicado: (2014)

The generation and function of soluble apoE receptors in the CNS
por: Rebeck, G William, et al.
Publicado: (2006)

Murine Gut Microbiome Association With APOE Alleles
por: Parikh, Ishita J., et al.
Publicado: (2020)

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform
por: Parikh, Ishita, et al.
Publicado: (2014)

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
por: Maldonado Weng, Juan, et al.
Publicado: (2019)

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition
por: Rodriguez, Gustavo A, et al.
Publicado: (2014)

Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer’s Disease Neuropathology and Genetics
por: Zajac, Diana J., et al.
Publicado: (2023)

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
por: Ling, I-Fang, et al.
Publicado: (2012)

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease
por: Wolf, Andrew B, et al.
Publicado: (2013)

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
por: Stephen, T. L., et al.
Publicado: (2019)

Combining genetic association study designs: a GWAS case study
por: Estus, Janice L., et al.
Publicado: (2013)

Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer’s Disease Risk Reveal a Potential Role for SIGLEC14
por: Shaw, Benjamin C., et al.
Publicado: (2021)

ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
por: Nwabuisi-Heath, Evelyn, et al.
Publicado: (2014)

Astroglial and microglial pathology in Down syndrome: Focus on Alzheimer's disease
por: García, Octavio, et al.
Publicado: (2022)

Ignited Minds
por: Minhas, Gillipsie
Publicado: (2013)

Longitudinal Trajectories of Cholesterol from Midlife through Late Life according to Apolipoprotein E Allele Status
por: Downer, Brian, et al.
Publicado: (2014)

Wildfires ignite concern.
por: Chepesiuk, R
Publicado: (2001)

CodeIgniter 17
por: Upton, David, et al.
Publicado: (2009)

Professional CodeIgniter
por: Myer, Thomas
Publicado: (2008)

Causes of Spontaneous Ignition
Publicado: (1873)

Igniting the sparkle : an indigenous science education model /
por: Cajete, Gregory, 1952-
Publicado: (1999)

The now habit at work: perform optimally, maintain focus, and ignite motivation in yourself and others
por: Fiore, Neil A
Publicado: (2010)

Elucidating the mechanisms underlying Alzheimer's disease-associated genetic polymorphisms
por: Estus, Steven
Publicado: (2012)

Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro
por: Ghura, Shivesh, et al.
Publicado: (2016)

Ignitability and explosibility of gases and vapors
por: Ma, Tingguang
Publicado: (2015)

ARDENT ignites research careers
por: Antonella Del Rosso
Publicado: (2013)

CodeIgniter 2 cookbook
por: Foster, Rob
Publicado: (2013)

Radiotherapy: the key to immunotherapy ignition?
por: Luterstein, Elaine, et al.
Publicado: (2017)

Accident from Ignition of Ether
Publicado: (1917)

Partially Premixed Ignition for a Bluff-Body Flameholder under Various Igniter and Inlet Conditions
por: Zhang, Yuxuan, et al.
Publicado: (2021)

Microglial Immunometabolism in Alzheimer’s Disease
por: Shippy, Daniel C., et al.
Publicado: (2020)

APOE2 is associated with longevity independent of Alzheimer’s disease
por: Shinohara, Mitsuru, et al.
Publicado: (2020)

Experimental and Numerical Study on Effect of Sample Orientation on Auto-Ignition and Piloted Ignition of Poly(methyl methacrylate)
por: Peng, Fei, et al.
Publicado: (2015)

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer’s disease risk genes
por: Kang, Silvia S., et al.
Publicado: (2016)

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
por: Jones, Nahdia S., et al.
Publicado: (2018)

Ignition and wave processes in combustion of solids
por: Rubtsov, Nickolai M, et al.
Publicado: (2017)

ATTRACT : Igniting the Deep Tech Revolution
Publicado: (2020)

Treatment of Gait Ignition Failure with Ropinirole
por: Cohen-Oram, Alexis N., et al.
Publicado: (2014)

Igniting stage two in Endocrine Connections
por: Köhrle, Josef
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_02fc8bb027s13fkj9j51bhrf1h