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Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context
Bile acids have recently been demonstrated as molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostases. They act mainly through two receptors, the nuclear receptor Farnesol-X-Receptor alpha (FXRα) and the G-protein coupled receptor (TGR...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595338/ https://www.ncbi.nlm.nih.gov/pubmed/26439743 http://dx.doi.org/10.1371/journal.pone.0139946 |
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author | Vega, Aurélie Martinot, Emmanuelle Baptissart, Marine De Haze, Angélique Vaz, Frederic Kulik, Wim Damon-Soubeyrand, Christelle Baron, Silvère Caira, Françoise Volle, David H. |
author_facet | Vega, Aurélie Martinot, Emmanuelle Baptissart, Marine De Haze, Angélique Vaz, Frederic Kulik, Wim Damon-Soubeyrand, Christelle Baron, Silvère Caira, Françoise Volle, David H. |
author_sort | Vega, Aurélie |
collection | PubMed |
description | Bile acids have recently been demonstrated as molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostases. They act mainly through two receptors, the nuclear receptor Farnesol-X-Receptor alpha (FXRα) and the G-protein coupled receptor (TGR5). These recent studies have led to the idea that molecules derived from bile acids (BAs) and targeting their receptors must be good targets for treatment of metabolic diseases such as obesity or diabetes. Thus it might be important to decipher the potential long term impact of such treatment on different physiological functions. Indeed, BAs have recently been demonstrated to alter male fertility. Here we demonstrate that in mice with overweight induced by high fat diet, BA exposure leads to increased rate of male infertility. This is associated with the altered germ cell proliferation, default of testicular endocrine function and abnormalities in cell-cell interaction within the seminiferous epithelium. Even if the identification of the exact molecular mechanisms will need more studies, the present results suggest that both FXRα and TGR5 might be involved. We believed that this work is of particular interest regarding the potential consequences on future approaches for the treatment of metabolic diseases. |
format | Online Article Text |
id | pubmed-4595338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45953382015-10-09 Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context Vega, Aurélie Martinot, Emmanuelle Baptissart, Marine De Haze, Angélique Vaz, Frederic Kulik, Wim Damon-Soubeyrand, Christelle Baron, Silvère Caira, Françoise Volle, David H. PLoS One Research Article Bile acids have recently been demonstrated as molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostases. They act mainly through two receptors, the nuclear receptor Farnesol-X-Receptor alpha (FXRα) and the G-protein coupled receptor (TGR5). These recent studies have led to the idea that molecules derived from bile acids (BAs) and targeting their receptors must be good targets for treatment of metabolic diseases such as obesity or diabetes. Thus it might be important to decipher the potential long term impact of such treatment on different physiological functions. Indeed, BAs have recently been demonstrated to alter male fertility. Here we demonstrate that in mice with overweight induced by high fat diet, BA exposure leads to increased rate of male infertility. This is associated with the altered germ cell proliferation, default of testicular endocrine function and abnormalities in cell-cell interaction within the seminiferous epithelium. Even if the identification of the exact molecular mechanisms will need more studies, the present results suggest that both FXRα and TGR5 might be involved. We believed that this work is of particular interest regarding the potential consequences on future approaches for the treatment of metabolic diseases. Public Library of Science 2015-10-06 /pmc/articles/PMC4595338/ /pubmed/26439743 http://dx.doi.org/10.1371/journal.pone.0139946 Text en © 2015 Vega et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Vega, Aurélie Martinot, Emmanuelle Baptissart, Marine De Haze, Angélique Vaz, Frederic Kulik, Wim Damon-Soubeyrand, Christelle Baron, Silvère Caira, Françoise Volle, David H. Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context |
title | Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context |
title_full | Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context |
title_fullStr | Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context |
title_full_unstemmed | Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context |
title_short | Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context |
title_sort | bile acid alters male mouse fertility in metabolic syndrome context |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595338/ https://www.ncbi.nlm.nih.gov/pubmed/26439743 http://dx.doi.org/10.1371/journal.pone.0139946 |
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