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Connecting Myokines and Metabolism
Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Endocrine Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595346/ https://www.ncbi.nlm.nih.gov/pubmed/26248861 http://dx.doi.org/10.3803/EnM.2015.30.3.235 |
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author | Ahima, Rexford S. Park, Hyeong-Kyu |
author_facet | Ahima, Rexford S. Park, Hyeong-Kyu |
author_sort | Ahima, Rexford S. |
collection | PubMed |
description | Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets. |
format | Online Article Text |
id | pubmed-4595346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-45953462015-10-13 Connecting Myokines and Metabolism Ahima, Rexford S. Park, Hyeong-Kyu Endocrinol Metab (Seoul) Review Article Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets. Korean Endocrine Society 2015-09 2015-08-04 /pmc/articles/PMC4595346/ /pubmed/26248861 http://dx.doi.org/10.3803/EnM.2015.30.3.235 Text en Copyright © 2015 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ahima, Rexford S. Park, Hyeong-Kyu Connecting Myokines and Metabolism |
title | Connecting Myokines and Metabolism |
title_full | Connecting Myokines and Metabolism |
title_fullStr | Connecting Myokines and Metabolism |
title_full_unstemmed | Connecting Myokines and Metabolism |
title_short | Connecting Myokines and Metabolism |
title_sort | connecting myokines and metabolism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595346/ https://www.ncbi.nlm.nih.gov/pubmed/26248861 http://dx.doi.org/10.3803/EnM.2015.30.3.235 |
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