Cargando…
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Endocrine Society
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595348/ https://www.ncbi.nlm.nih.gov/pubmed/26435130 http://dx.doi.org/10.3803/EnM.2015.30.3.252 |
_version_ | 1782393591715332096 |
---|---|
author | Song, Young Shin Lim, Jung Ah Park, Young Joo |
author_facet | Song, Young Shin Lim, Jung Ah Park, Young Joo |
author_sort | Song, Young Shin |
collection | PubMed |
description | Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor γ (PPARγ) rearrangements. Beyond these more common mutations, alterations in the telomerase reverse transcriptase (TERT) promoter have recently been associated with clinicopathologic features, disease prognosis, and tumorigenesis in thyroid cancer. While the mutations underlying thyroid tumorigenesis are well known, the frequency of these mutations is strongly associated with geography, with clear differences reported between Asian and Western countries. Of particular interest is the prevalence of BRAF mutations, with Korean patients exhibiting the highest rate of BRAF-associated thyroid cancers in the world. Here, we review the prevalence of each of the most common mutations in Asian and Western countries, and identify the characteristics of well-differentiated thyroid cancer in Asians. |
format | Online Article Text |
id | pubmed-4595348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-45953482015-10-13 Mutation Profile of Well-Differentiated Thyroid Cancer in Asians Song, Young Shin Lim, Jung Ah Park, Young Joo Endocrinol Metab (Seoul) Review Article Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor γ (PPARγ) rearrangements. Beyond these more common mutations, alterations in the telomerase reverse transcriptase (TERT) promoter have recently been associated with clinicopathologic features, disease prognosis, and tumorigenesis in thyroid cancer. While the mutations underlying thyroid tumorigenesis are well known, the frequency of these mutations is strongly associated with geography, with clear differences reported between Asian and Western countries. Of particular interest is the prevalence of BRAF mutations, with Korean patients exhibiting the highest rate of BRAF-associated thyroid cancers in the world. Here, we review the prevalence of each of the most common mutations in Asian and Western countries, and identify the characteristics of well-differentiated thyroid cancer in Asians. Korean Endocrine Society 2015-09 2015-09-22 /pmc/articles/PMC4595348/ /pubmed/26435130 http://dx.doi.org/10.3803/EnM.2015.30.3.252 Text en Copyright © 2015 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Song, Young Shin Lim, Jung Ah Park, Young Joo Mutation Profile of Well-Differentiated Thyroid Cancer in Asians |
title | Mutation Profile of Well-Differentiated Thyroid Cancer in Asians |
title_full | Mutation Profile of Well-Differentiated Thyroid Cancer in Asians |
title_fullStr | Mutation Profile of Well-Differentiated Thyroid Cancer in Asians |
title_full_unstemmed | Mutation Profile of Well-Differentiated Thyroid Cancer in Asians |
title_short | Mutation Profile of Well-Differentiated Thyroid Cancer in Asians |
title_sort | mutation profile of well-differentiated thyroid cancer in asians |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595348/ https://www.ncbi.nlm.nih.gov/pubmed/26435130 http://dx.doi.org/10.3803/EnM.2015.30.3.252 |
work_keys_str_mv | AT songyoungshin mutationprofileofwelldifferentiatedthyroidcancerinasians AT limjungah mutationprofileofwelldifferentiatedthyroidcancerinasians AT parkyoungjoo mutationprofileofwelldifferentiatedthyroidcancerinasians |