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Analyzing and Quantifying the Gain-of-Function Enhancement of IP(3) Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins

Familial Alzheimer’s disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) Ca(2+) release channels resulting in enhanced IP(3)R channel gating in an amyloid beta (Aβ) production-independent manner. This gain-of-function enhancement of IP(3...

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Detalles Bibliográficos
Autores principales:	Mak, Don-On Daniel, Cheung, King-Ho, Toglia, Patrick, Foskett, J. Kevin, Ullah, Ghanim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595473/ https://www.ncbi.nlm.nih.gov/pubmed/26439382 http://dx.doi.org/10.1371/journal.pcbi.1004529

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