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An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands
The anterior cingulate and lateral prefrontal cortices have been implicated in implementing context-appropriate attentional control, but the learning mechanisms underlying our ability to flexibly adapt the control settings to changing environments remain poorly understood. Here we show that human ad...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595591/ https://www.ncbi.nlm.nih.gov/pubmed/26391305 http://dx.doi.org/10.1038/ncomms9165 |
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author | Jiang, Jiefeng Beck, Jeffrey Heller, Katherine Egner, Tobias |
author_facet | Jiang, Jiefeng Beck, Jeffrey Heller, Katherine Egner, Tobias |
author_sort | Jiang, Jiefeng |
collection | PubMed |
description | The anterior cingulate and lateral prefrontal cortices have been implicated in implementing context-appropriate attentional control, but the learning mechanisms underlying our ability to flexibly adapt the control settings to changing environments remain poorly understood. Here we show that human adjustments to varying control demands are captured by a reinforcement learner with a flexible, volatility-driven learning rate. Using model-based functional magnetic resonance imaging, we demonstrate that volatility of control demand is estimated by the anterior insula, which in turn optimizes the prediction of forthcoming demand in the caudate nucleus. The caudate's prediction of control demand subsequently guides the implementation of proactive and reactive attentional control in dorsal anterior cingulate and dorsolateral prefrontal cortices. These data enhance our understanding of the neuro-computational mechanisms of adaptive behaviour by connecting the classic cingulate-prefrontal cognitive control network to a subcortical control-learning mechanism that infers future demands by flexibly integrating remote and recent past experiences. |
format | Online Article Text |
id | pubmed-4595591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45955912015-10-21 An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands Jiang, Jiefeng Beck, Jeffrey Heller, Katherine Egner, Tobias Nat Commun Article The anterior cingulate and lateral prefrontal cortices have been implicated in implementing context-appropriate attentional control, but the learning mechanisms underlying our ability to flexibly adapt the control settings to changing environments remain poorly understood. Here we show that human adjustments to varying control demands are captured by a reinforcement learner with a flexible, volatility-driven learning rate. Using model-based functional magnetic resonance imaging, we demonstrate that volatility of control demand is estimated by the anterior insula, which in turn optimizes the prediction of forthcoming demand in the caudate nucleus. The caudate's prediction of control demand subsequently guides the implementation of proactive and reactive attentional control in dorsal anterior cingulate and dorsolateral prefrontal cortices. These data enhance our understanding of the neuro-computational mechanisms of adaptive behaviour by connecting the classic cingulate-prefrontal cognitive control network to a subcortical control-learning mechanism that infers future demands by flexibly integrating remote and recent past experiences. Nature Pub. Group 2015-09-22 /pmc/articles/PMC4595591/ /pubmed/26391305 http://dx.doi.org/10.1038/ncomms9165 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Jiang, Jiefeng Beck, Jeffrey Heller, Katherine Egner, Tobias An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
title | An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
title_full | An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
title_fullStr | An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
title_full_unstemmed | An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
title_short | An insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
title_sort | insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595591/ https://www.ncbi.nlm.nih.gov/pubmed/26391305 http://dx.doi.org/10.1038/ncomms9165 |
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