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Synaptic remodeling of neuronal circuits in early retinal degeneration
Photoreceptor degenerations are a major cause of blindness and among the most common forms of neurodegeneration in humans. Studies of mouse models revealed that synaptic dysfunction often precedes photoreceptor degeneration, and that abnormal synaptic input from photoreceptors to bipolar cells cause...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595653/ https://www.ncbi.nlm.nih.gov/pubmed/26500497 http://dx.doi.org/10.3389/fncel.2015.00395 |
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author | Soto, Florentina Kerschensteiner, Daniel |
author_facet | Soto, Florentina Kerschensteiner, Daniel |
author_sort | Soto, Florentina |
collection | PubMed |
description | Photoreceptor degenerations are a major cause of blindness and among the most common forms of neurodegeneration in humans. Studies of mouse models revealed that synaptic dysfunction often precedes photoreceptor degeneration, and that abnormal synaptic input from photoreceptors to bipolar cells causes circuits in the inner retina to become hyperactive. Here, we provide a brief overview of frequently used mouse models of photoreceptor degenerations. We then discuss insights into circuit remodeling triggered by early synaptic dysfunction in the outer and hyperactivity in the inner retina. We discuss these insights in the context of other experimental manipulations of synaptic function and activity. Knowledge of the plasticity and early remodeling of retinal circuits will be critical for the design of successful vision rescue strategies. |
format | Online Article Text |
id | pubmed-4595653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45956532015-10-23 Synaptic remodeling of neuronal circuits in early retinal degeneration Soto, Florentina Kerschensteiner, Daniel Front Cell Neurosci Neuroscience Photoreceptor degenerations are a major cause of blindness and among the most common forms of neurodegeneration in humans. Studies of mouse models revealed that synaptic dysfunction often precedes photoreceptor degeneration, and that abnormal synaptic input from photoreceptors to bipolar cells causes circuits in the inner retina to become hyperactive. Here, we provide a brief overview of frequently used mouse models of photoreceptor degenerations. We then discuss insights into circuit remodeling triggered by early synaptic dysfunction in the outer and hyperactivity in the inner retina. We discuss these insights in the context of other experimental manipulations of synaptic function and activity. Knowledge of the plasticity and early remodeling of retinal circuits will be critical for the design of successful vision rescue strategies. Frontiers Media S.A. 2015-10-07 /pmc/articles/PMC4595653/ /pubmed/26500497 http://dx.doi.org/10.3389/fncel.2015.00395 Text en Copyright © 2015 Soto and Kerschensteiner. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Soto, Florentina Kerschensteiner, Daniel Synaptic remodeling of neuronal circuits in early retinal degeneration |
title | Synaptic remodeling of neuronal circuits in early retinal degeneration |
title_full | Synaptic remodeling of neuronal circuits in early retinal degeneration |
title_fullStr | Synaptic remodeling of neuronal circuits in early retinal degeneration |
title_full_unstemmed | Synaptic remodeling of neuronal circuits in early retinal degeneration |
title_short | Synaptic remodeling of neuronal circuits in early retinal degeneration |
title_sort | synaptic remodeling of neuronal circuits in early retinal degeneration |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595653/ https://www.ncbi.nlm.nih.gov/pubmed/26500497 http://dx.doi.org/10.3389/fncel.2015.00395 |
work_keys_str_mv | AT sotoflorentina synapticremodelingofneuronalcircuitsinearlyretinaldegeneration AT kerschensteinerdaniel synapticremodelingofneuronalcircuitsinearlyretinaldegeneration |