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Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1

Ornithine decarboxylase (ODC) catalyzes the first and rate-limiting step of polyamine biosynthesis in humans. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Excessive accumulation of polyamines has a cytotoxic effe...

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Detalles Bibliográficos
Autores principales:	Wu, Donghui, Kaan, Hung Yi Kristal, Zheng, Xiaoxia, Tang, Xuhua, He, Yang, Vanessa Tan, Qianmin, Zhang, Neng, Song, Haiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595762/ https://www.ncbi.nlm.nih.gov/pubmed/26443277 http://dx.doi.org/10.1038/srep14738

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