Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation

Sirtuin-7 (SIRT7) deacetylase exhibits a high selectivity for acetylated H3K18 and has been implicated in the maintenance of malignant phenotype. However, it remains unclear if SIRT7 and H3K18ac play a role in the tumorigenic program driven by oncogenic viruses. We show that ectopically expressed HB...

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Detalles Bibliográficos
Autores principales: Pandey, Vijaya, Kumar, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595800/
https://www.ncbi.nlm.nih.gov/pubmed/26442981
http://dx.doi.org/10.1038/srep14806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595800/
https://www.ncbi.nlm.nih.gov/pubmed/26442981
http://dx.doi.org/10.1038/srep14806

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