Cargando…
Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis
PURPOSE: Pancreatic body/tail cancer often involves the celiac axis (CA) and it is regarded as an unresectable disease. To treat the disease, we employed distal pancreatectomy with en bloc celiac axis resection (DP-CAR) and reviewed our experiences. METHODS: We performed DP-CAR for seven patients wi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595816/ https://www.ncbi.nlm.nih.gov/pubmed/26446424 http://dx.doi.org/10.4174/astr.2015.89.4.167 |
_version_ | 1782393674244554752 |
---|---|
author | Ham, Hyemin Kim, Sang Geol Kwon, Hyung Jun Ha, Heontak Choi, Young Yeon |
author_facet | Ham, Hyemin Kim, Sang Geol Kwon, Hyung Jun Ha, Heontak Choi, Young Yeon |
author_sort | Ham, Hyemin |
collection | PubMed |
description | PURPOSE: Pancreatic body/tail cancer often involves the celiac axis (CA) and it is regarded as an unresectable disease. To treat the disease, we employed distal pancreatectomy with en bloc celiac axis resection (DP-CAR) and reviewed our experiences. METHODS: We performed DP-CAR for seven patients with pancreatic body/tail cancer involving the CA. The indications of DP-CAR initially included tumors with definite invasion of CA and were later expanded to include borderline resectable disease. To determine the efficacy of DP-CAR, the clinico-pathological data of patients who underwent DP-CAR were compared to both distal pancreatectomy (DP) group and no resection (NR) group. RESULTS: The R0 resection rate was 71.4% and was not statistically different compared to DP group. The operative time (P = 0.018) and length of hospital stay (P = 0.022) were significantly longer in DP-CAR group but no significant difference was found in incidence of the postoperative pancreatic fistula compared to DP group. In DP-CAR group, focal hepatic infarction and transient hepatopathy occurred in 1 patient and 3 patients, respectively. No mortality occurred in DP-CAR group. The median survival time (MST) was not statistically different compared to DP group. However, the MST of DP-CAR group was significantly longer than that of NR group (P < 0.001). CONCLUSION: In our experience, DP-CAR was safe and offered high R0 resection rate for patients with pancreatic body/tail cancer with involvement of CA. The effect on survival of DP-CAR is comparable to DP and better than that of NR. However, the benefits need to be verified by further studies in the future. |
format | Online Article Text |
id | pubmed-4595816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-45958162015-10-07 Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis Ham, Hyemin Kim, Sang Geol Kwon, Hyung Jun Ha, Heontak Choi, Young Yeon Ann Surg Treat Res Original Article PURPOSE: Pancreatic body/tail cancer often involves the celiac axis (CA) and it is regarded as an unresectable disease. To treat the disease, we employed distal pancreatectomy with en bloc celiac axis resection (DP-CAR) and reviewed our experiences. METHODS: We performed DP-CAR for seven patients with pancreatic body/tail cancer involving the CA. The indications of DP-CAR initially included tumors with definite invasion of CA and were later expanded to include borderline resectable disease. To determine the efficacy of DP-CAR, the clinico-pathological data of patients who underwent DP-CAR were compared to both distal pancreatectomy (DP) group and no resection (NR) group. RESULTS: The R0 resection rate was 71.4% and was not statistically different compared to DP group. The operative time (P = 0.018) and length of hospital stay (P = 0.022) were significantly longer in DP-CAR group but no significant difference was found in incidence of the postoperative pancreatic fistula compared to DP group. In DP-CAR group, focal hepatic infarction and transient hepatopathy occurred in 1 patient and 3 patients, respectively. No mortality occurred in DP-CAR group. The median survival time (MST) was not statistically different compared to DP group. However, the MST of DP-CAR group was significantly longer than that of NR group (P < 0.001). CONCLUSION: In our experience, DP-CAR was safe and offered high R0 resection rate for patients with pancreatic body/tail cancer with involvement of CA. The effect on survival of DP-CAR is comparable to DP and better than that of NR. However, the benefits need to be verified by further studies in the future. The Korean Surgical Society 2015-10 2015-09-25 /pmc/articles/PMC4595816/ /pubmed/26446424 http://dx.doi.org/10.4174/astr.2015.89.4.167 Text en Copyright © 2015, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ham, Hyemin Kim, Sang Geol Kwon, Hyung Jun Ha, Heontak Choi, Young Yeon Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
title | Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
title_full | Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
title_fullStr | Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
title_full_unstemmed | Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
title_short | Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
title_sort | distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595816/ https://www.ncbi.nlm.nih.gov/pubmed/26446424 http://dx.doi.org/10.4174/astr.2015.89.4.167 |
work_keys_str_mv | AT hamhyemin distalpancreatectomywithceliacaxisresectionforpancreaticbodyandtailcancerinvadingceliacaxis AT kimsanggeol distalpancreatectomywithceliacaxisresectionforpancreaticbodyandtailcancerinvadingceliacaxis AT kwonhyungjun distalpancreatectomywithceliacaxisresectionforpancreaticbodyandtailcancerinvadingceliacaxis AT haheontak distalpancreatectomywithceliacaxisresectionforpancreaticbodyandtailcancerinvadingceliacaxis AT choiyoungyeon distalpancreatectomywithceliacaxisresectionforpancreaticbodyandtailcancerinvadingceliacaxis |