Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity

Human dihydroorotate dehydrogenase (hDHODH) is an attractive therapeutic target for the treatment of rheumatoid arthritis, transplant rejection and other autoimmune diseases. Based on the X-ray structure of hDHODH in complex with lead compound 7, a series of benzylidenehydrazinyl-substituted thiazol...

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Detalles Bibliográficos
Autores principales: Li, Shiliang, Luan, Guoqin, Ren, Xiaoli, Song, Wenlin, Xu, Liuxin, Xu, Minghao, Zhu, Junsheng, Dong, Dong, Diao, Yanyan, Liu, Xiaofeng, Zhu, Lili, Wang, Rui, Zhao, Zhenjiang, Xu, Yufang, Li, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595849/
https://www.ncbi.nlm.nih.gov/pubmed/26443076
http://dx.doi.org/10.1038/srep14836

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