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Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis
OBJECTIVES: To determine and compare the effects of autologous platelet rich plasma (PRP) and hyaluronic acid (HA) for the treatment of osteoarthritis of the knee. METHODS: This prospective study included 150 patients affected by severe osteoarthritis of the knee. Gonarthrosis was graded using the K...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595873/ http://dx.doi.org/10.1177/2325967114S00240 |
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author | Holguin, Esteban |
author_facet | Holguin, Esteban |
author_sort | Holguin, Esteban |
collection | PubMed |
description | OBJECTIVES: To determine and compare the effects of autologous platelet rich plasma (PRP) and hyaluronic acid (HA) for the treatment of osteoarthritis of the knee. METHODS: This prospective study included 150 patients affected by severe osteoarthritis of the knee. Gonarthrosis was graded using the Kellgren-Lawrence and Albhack radiographic classification scale. 150 patients were randomized into 2 study groups .In the PRP group (n=55) three intraarticular injection were applied andthe control group (n=55) received 3 intra-articular injections of high molecular weight HA. An unblinded physician performed infiltration once a week for 3 weeks into the knee affected by clinically relevant gonarthrosis (in both groups). All patients were evaluated with the Western Ontario and McMaster (WOMAC) score and visual pain scale before the infiltration and at 3, 6, and 12 months after the first injection. RESULTS: No severe adverse events was observed. Statistically significant better results in the WOMAC score and visual pain scale was determined in PRP group than HA group at 3 months and 6 months follow up. The cost of the application for the PRP group was lower than that of the HA group.At 12 months' of follow-up, PRP and HA treatments offered similar results. CONCLUSION: The results of this study have shown the application of autologousPRP to be a safe, effective and low-cost method for treating OA tan HA. However, further studies are required for a more clear result |
format | Online Article Text |
id | pubmed-4595873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-45958732015-11-03 Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis Holguin, Esteban Orthop J Sports Med Article OBJECTIVES: To determine and compare the effects of autologous platelet rich plasma (PRP) and hyaluronic acid (HA) for the treatment of osteoarthritis of the knee. METHODS: This prospective study included 150 patients affected by severe osteoarthritis of the knee. Gonarthrosis was graded using the Kellgren-Lawrence and Albhack radiographic classification scale. 150 patients were randomized into 2 study groups .In the PRP group (n=55) three intraarticular injection were applied andthe control group (n=55) received 3 intra-articular injections of high molecular weight HA. An unblinded physician performed infiltration once a week for 3 weeks into the knee affected by clinically relevant gonarthrosis (in both groups). All patients were evaluated with the Western Ontario and McMaster (WOMAC) score and visual pain scale before the infiltration and at 3, 6, and 12 months after the first injection. RESULTS: No severe adverse events was observed. Statistically significant better results in the WOMAC score and visual pain scale was determined in PRP group than HA group at 3 months and 6 months follow up. The cost of the application for the PRP group was lower than that of the HA group.At 12 months' of follow-up, PRP and HA treatments offered similar results. CONCLUSION: The results of this study have shown the application of autologousPRP to be a safe, effective and low-cost method for treating OA tan HA. However, further studies are required for a more clear result SAGE Publications 2015-01-05 /pmc/articles/PMC4595873/ http://dx.doi.org/10.1177/2325967114S00240 Text en © The Author(s) 2014 http://creativecommons.org/licenses/by-nc-nd/3.0/ This open-access article is published and distributed under the Creative Commons Attribution - NonCommercial - No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article without the permission of the Author(s). For reprints and permission queries, please visit SAGE’s Web site at http://www.sagepub.com/journalsPermissions.nav. |
spellingShingle | Article Holguin, Esteban Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
title | Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
title_full | Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
title_fullStr | Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
title_full_unstemmed | Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
title_short | Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
title_sort | platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595873/ http://dx.doi.org/10.1177/2325967114S00240 |
work_keys_str_mv | AT holguinesteban plateletrichplasmainjectionismoreeffectivethanhyaluronicacidinthetreatmentofkneeosteoarthritis |