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Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB

AcrB is the inner membrane transporter of the tripartite multidrug efflux pump AcrAB-TolC in E. coli, which poses a major obstacle to the treatment of bacterial infections. X-ray structures have identified two types of substrate-binding pockets in the porter domains of AcrB trimer: the proximal bind...

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Detalles Bibliográficos
Autores principales:	Zuo, Zhicheng, Wang, Beibei, Weng, Jingwei, Wang, Wenning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595977/ https://www.ncbi.nlm.nih.gov/pubmed/26365278 http://dx.doi.org/10.1038/srep13905

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