Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome1,2,3

Mutations in a voltage-gated sodium channel (SCN1A) result in Dravet Syndrome (DS), a catastrophic childhood epilepsy. Zebrafish with a mutation in scn1Lab recapitulate salient phenotypes associated with DS, including seizures, early fatality, and resistance to antiepileptic drugs. To discover new d...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinday, Matthew T., Baraban, Scott C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2015
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596025/
https://www.ncbi.nlm.nih.gov/pubmed/26465006
http://dx.doi.org/10.1523/ENEURO.0068-15.2015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596025/
https://www.ncbi.nlm.nih.gov/pubmed/26465006
http://dx.doi.org/10.1523/ENEURO.0068-15.2015

Ejemplares similares