Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gav...

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Autores principales: Jameson, Victoria J.A., Cochemé, Helena M., Logan, Angela, Hanton, Lyall R., Smith, Robin A.J., Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596152/
https://www.ncbi.nlm.nih.gov/pubmed/26549895
http://dx.doi.org/10.1016/j.tet.2015.09.014
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author Jameson, Victoria J.A.
Cochemé, Helena M.
Logan, Angela
Hanton, Lyall R.
Smith, Robin A.J.
Murphy, Michael P.
author_facet Jameson, Victoria J.A.
Cochemé, Helena M.
Logan, Angela
Hanton, Lyall R.
Smith, Robin A.J.
Murphy, Michael P.
author_sort Jameson, Victoria J.A.
collection PubMed
description A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo.
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spelling pubmed-45961522015-11-04 Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants Jameson, Victoria J.A. Cochemé, Helena M. Logan, Angela Hanton, Lyall R. Smith, Robin A.J. Murphy, Michael P. Tetrahedron Article A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo. Pergamon Press 2015-11-04 /pmc/articles/PMC4596152/ /pubmed/26549895 http://dx.doi.org/10.1016/j.tet.2015.09.014 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jameson, Victoria J.A.
Cochemé, Helena M.
Logan, Angela
Hanton, Lyall R.
Smith, Robin A.J.
Murphy, Michael P.
Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
title Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
title_full Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
title_fullStr Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
title_full_unstemmed Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
title_short Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
title_sort synthesis of triphenylphosphonium vitamin e derivatives as mitochondria-targeted antioxidants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596152/
https://www.ncbi.nlm.nih.gov/pubmed/26549895
http://dx.doi.org/10.1016/j.tet.2015.09.014
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