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Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gav...
Autores principales: | Jameson, Victoria J.A., Cochemé, Helena M., Logan, Angela, Hanton, Lyall R., Smith, Robin A.J., Murphy, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pergamon Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596152/ https://www.ncbi.nlm.nih.gov/pubmed/26549895 http://dx.doi.org/10.1016/j.tet.2015.09.014 |
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