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Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors

Antibody-dependent cellular cytotoxicity (ADCC) is an important effector function determining the clinical efficacy of therapeutic antibodies. Core fucose removal from N-glycans on the Fc portion of immunoglobulin G (IgG) improves the binding affinity for Fcγ receptor IIIa (FcγRIIIa) and dramaticall...

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Detalles Bibliográficos
Autores principales:	Isoda, Yuya, Yagi, Hirokazu, Satoh, Tadashi, Shibata-Koyama, Mami, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi, Iida, Shigeru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596520/ https://www.ncbi.nlm.nih.gov/pubmed/26444434 http://dx.doi.org/10.1371/journal.pone.0140120

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