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Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal

Seasonal malaria chemoprevention (SMC) is defined as the intermittent administration of full treatment courses of an antimalarial drug to children during the peak of malaria transmission season with the aim of preventing malaria-associated mortality and morbidity. SMC using sulfadoxine–pyrimethamine...

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Autores principales: Ndiaye, Magatte, Sylla, Khadime, Sow, Doudou, Tine, Roger, Faye, Babacar, Ndiaye, Jean Louis, Dieng, Yemou, Lo, Aminata Collé, Abiola, Annie, Cisse, Badara, Ndiaye, Daouda, Theisen, Michael, Gaye, Oumar, Alifrangis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596602/
https://www.ncbi.nlm.nih.gov/pubmed/26283746
http://dx.doi.org/10.4269/ajtmh.14-0808
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author Ndiaye, Magatte
Sylla, Khadime
Sow, Doudou
Tine, Roger
Faye, Babacar
Ndiaye, Jean Louis
Dieng, Yemou
Lo, Aminata Collé
Abiola, Annie
Cisse, Badara
Ndiaye, Daouda
Theisen, Michael
Gaye, Oumar
Alifrangis, Michael
author_facet Ndiaye, Magatte
Sylla, Khadime
Sow, Doudou
Tine, Roger
Faye, Babacar
Ndiaye, Jean Louis
Dieng, Yemou
Lo, Aminata Collé
Abiola, Annie
Cisse, Badara
Ndiaye, Daouda
Theisen, Michael
Gaye, Oumar
Alifrangis, Michael
author_sort Ndiaye, Magatte
collection PubMed
description Seasonal malaria chemoprevention (SMC) is defined as the intermittent administration of full treatment courses of an antimalarial drug to children during the peak of malaria transmission season with the aim of preventing malaria-associated mortality and morbidity. SMC using sulfadoxine–pyrimethamine (SP) combined with amodiaquine (AQ) is a promising strategy to control malaria morbidity in areas of highly seasonal malaria transmission. However, a concern is whether SMC can delay the natural acquisition of immunity toward malaria parasites in areas with intense SMC delivery. To investigate this, total IgG antibody (Ab) responses to Plasmodium falciparum antigens glutamate-rich protein R0 (GLURP-R0) and apical membrane antigen 1 (AMA-1) were measured by enzyme-linked immunosorbent assay in Senegalese children under the age of 10 years in 2010 living in Saraya and Velingara districts (with SMC using SP+AQ [SMC+] since 2007) and Tambacounda district (without SMC (SMC−)). For both P. falciparum antigens, total IgG response were significantly higher in the SMC− compared with the SMC+ group (for GLURP-R0, P < 0.001 and for AMA-1, P = 0.001). There was as well a nonsignificant tendency for higher percentage of positive responders in the SMC− compared with the SMC+ group (for GLURP-R0: 22.2% versus 14.4%, respectively [P = 0.06]; for AMA-1: 45.6% versus 40.0%, respectively [P = 0.24]). Results suggest that long-term malaria chemoprevention by SMC/SP+AQ have limited impact on the development of acquired immunity, as tested using the P. falciparum antigens GLURP-R0 and AMA-1. However, other factors, not measured in this study, may interfere as well.
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spelling pubmed-45966022015-10-16 Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal Ndiaye, Magatte Sylla, Khadime Sow, Doudou Tine, Roger Faye, Babacar Ndiaye, Jean Louis Dieng, Yemou Lo, Aminata Collé Abiola, Annie Cisse, Badara Ndiaye, Daouda Theisen, Michael Gaye, Oumar Alifrangis, Michael Am J Trop Med Hyg Articles Seasonal malaria chemoprevention (SMC) is defined as the intermittent administration of full treatment courses of an antimalarial drug to children during the peak of malaria transmission season with the aim of preventing malaria-associated mortality and morbidity. SMC using sulfadoxine–pyrimethamine (SP) combined with amodiaquine (AQ) is a promising strategy to control malaria morbidity in areas of highly seasonal malaria transmission. However, a concern is whether SMC can delay the natural acquisition of immunity toward malaria parasites in areas with intense SMC delivery. To investigate this, total IgG antibody (Ab) responses to Plasmodium falciparum antigens glutamate-rich protein R0 (GLURP-R0) and apical membrane antigen 1 (AMA-1) were measured by enzyme-linked immunosorbent assay in Senegalese children under the age of 10 years in 2010 living in Saraya and Velingara districts (with SMC using SP+AQ [SMC+] since 2007) and Tambacounda district (without SMC (SMC−)). For both P. falciparum antigens, total IgG response were significantly higher in the SMC− compared with the SMC+ group (for GLURP-R0, P < 0.001 and for AMA-1, P = 0.001). There was as well a nonsignificant tendency for higher percentage of positive responders in the SMC− compared with the SMC+ group (for GLURP-R0: 22.2% versus 14.4%, respectively [P = 0.06]; for AMA-1: 45.6% versus 40.0%, respectively [P = 0.24]). Results suggest that long-term malaria chemoprevention by SMC/SP+AQ have limited impact on the development of acquired immunity, as tested using the P. falciparum antigens GLURP-R0 and AMA-1. However, other factors, not measured in this study, may interfere as well. The American Society of Tropical Medicine and Hygiene 2015-10-07 /pmc/articles/PMC4596602/ /pubmed/26283746 http://dx.doi.org/10.4269/ajtmh.14-0808 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Ndiaye, Magatte
Sylla, Khadime
Sow, Doudou
Tine, Roger
Faye, Babacar
Ndiaye, Jean Louis
Dieng, Yemou
Lo, Aminata Collé
Abiola, Annie
Cisse, Badara
Ndiaye, Daouda
Theisen, Michael
Gaye, Oumar
Alifrangis, Michael
Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal
title Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal
title_full Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal
title_fullStr Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal
title_full_unstemmed Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal
title_short Potential Impact of Seasonal Malaria Chemoprevention on the Acquisition of Antibodies against Glutamate-Rich Protein and Apical Membrane Antigen 1 in Children Living in Southern Senegal
title_sort potential impact of seasonal malaria chemoprevention on the acquisition of antibodies against glutamate-rich protein and apical membrane antigen 1 in children living in southern senegal
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596602/
https://www.ncbi.nlm.nih.gov/pubmed/26283746
http://dx.doi.org/10.4269/ajtmh.14-0808
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