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Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans

FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling....

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Detalles Bibliográficos
Autores principales:	Chen, Albert Tzong-Yang, Guo, Chunfang, Itani, Omar A., Budaitis, Breane G., Williams, Travis W., Hopkins, Christopher E., McEachin, Richard C., Pande, Manjusha, Grant, Ana R., Yoshina, Sawako, Mitani, Shohei, Hu, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2015
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596673/ https://www.ncbi.nlm.nih.gov/pubmed/26219299 http://dx.doi.org/10.1534/genetics.115.177998

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