Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess

Klebsiella liver abscess (KLA) is an emerging infection in Asia caused by hypermucoviscous strains of Klebsiella pneumoniae. It is associated with thrombophlebitis of portal and hepatic veins. The natural history and role of anticoagulation for this regional thrombophlebitis is unclear. In a retrosp...

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Detalles Bibliográficos
Autores principales: Molton, James S., Chee, Yen Lin, Hennedige, Tiffany P., Venkatesh, Sudhakar K., Archuleta, Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596830/
https://www.ncbi.nlm.nih.gov/pubmed/26444702
http://dx.doi.org/10.1371/journal.pone.0140129
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author Molton, James S.
Chee, Yen Lin
Hennedige, Tiffany P.
Venkatesh, Sudhakar K.
Archuleta, Sophia
author_facet Molton, James S.
Chee, Yen Lin
Hennedige, Tiffany P.
Venkatesh, Sudhakar K.
Archuleta, Sophia
author_sort Molton, James S.
collection PubMed
description Klebsiella liver abscess (KLA) is an emerging infection in Asia caused by hypermucoviscous strains of Klebsiella pneumoniae. It is associated with thrombophlebitis of portal and hepatic veins. The natural history and role of anticoagulation for this regional thrombophlebitis is unclear. In a retrospective study of 169 subjects with KLA over 7 years, thrombophlebitis was identified in 53/169 (31.4%). Only 1 received therapeutic anticoagulation. Despite this 30/49 (73.2%) of those with follow up scan available showed improvement or recanalization (mean duration between scans 44 days). Abscess resolution was associated with improvement in thrombophlebitis.
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spelling pubmed-45968302015-10-20 Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess Molton, James S. Chee, Yen Lin Hennedige, Tiffany P. Venkatesh, Sudhakar K. Archuleta, Sophia PLoS One Research Article Klebsiella liver abscess (KLA) is an emerging infection in Asia caused by hypermucoviscous strains of Klebsiella pneumoniae. It is associated with thrombophlebitis of portal and hepatic veins. The natural history and role of anticoagulation for this regional thrombophlebitis is unclear. In a retrospective study of 169 subjects with KLA over 7 years, thrombophlebitis was identified in 53/169 (31.4%). Only 1 received therapeutic anticoagulation. Despite this 30/49 (73.2%) of those with follow up scan available showed improvement or recanalization (mean duration between scans 44 days). Abscess resolution was associated with improvement in thrombophlebitis. Public Library of Science 2015-10-07 /pmc/articles/PMC4596830/ /pubmed/26444702 http://dx.doi.org/10.1371/journal.pone.0140129 Text en © 2015 Molton et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Molton, James S.
Chee, Yen Lin
Hennedige, Tiffany P.
Venkatesh, Sudhakar K.
Archuleta, Sophia
Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess
title Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess
title_full Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess
title_fullStr Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess
title_full_unstemmed Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess
title_short Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess
title_sort impact of regional vein thrombosis in patients with klebsiella pneumoniae liver abscess
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596830/
https://www.ncbi.nlm.nih.gov/pubmed/26444702
http://dx.doi.org/10.1371/journal.pone.0140129
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