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Inflammation Induces TDP-43 Mislocalization and Aggregation

TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we report that lipopolysaccharide (LPS)-induced inflammation can promote TDP-43 mislocalization and aggregation....

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Detalles Bibliográficos
Autores principales:	Correia, Ana Sofia, Patel, Priyanka, Dutta, Kallol, Julien, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596857/ https://www.ncbi.nlm.nih.gov/pubmed/26444430 http://dx.doi.org/10.1371/journal.pone.0140248

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