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Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus

Some animals and humans fed a high-energy diet (HED) are diet-resistant (DR), remaining as lean as individuals who were naïve to HED. Other individuals become obese during HED exposure and subsequently defend the obese weight (Diet-Induced Obesity- Defenders, DIO-D) even when subsequently maintained...

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Detalles Bibliográficos
Autores principales: Luchtman, Dirk W., Chee, Melissa J. S., Doslikova, Barbora, Marks, Daniel L., Baracos, Vickie E., Colmers, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596859/
https://www.ncbi.nlm.nih.gov/pubmed/26444289
http://dx.doi.org/10.1371/journal.pone.0139462