Cargando…

Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells

Maternally Expressed Gene 3 (MEG3) encodes a lncRNA which is suggested to function as a tumor suppressor. Previous studies suggested that MEG3 functioned through activation of p53, however, the functional properties of MEG3 remain obscure and their relevance to human diseases is under continuous inv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Juanjuan, Liu, Shanshan, Ye, Fuqiang, Shen, Yuan, Tie, Yi, Zhu, Jie, Wei, Lixin, Jin, Yinghua, Fu, Hanjiang, Wu, Yongge, Zheng, Xiaofei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596861/ https://www.ncbi.nlm.nih.gov/pubmed/26444285 http://dx.doi.org/10.1371/journal.pone.0139790

Ejemplares similares

The Long Noncoding RNA Expression Profile of Hepatocellular Carcinoma Identified by Microarray Analysis
por: Zhu, Juanjuan, et al.
Publicado: (2014)

Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP
por: Chen, Yajie, et al.
Publicado: (2021)

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway
por: Uroda, Tina, et al.
Publicado: (2019)

Dihydromyricetin Reduced Bcl-2 Expression via p53 in Human Hepatoma HepG2 Cells
por: Wu, Shixing, et al.
Publicado: (2013)

Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways
por: Zhao, Bixing, et al.
Publicado: (2014)

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9
por: Tian, Xiaobing, et al.
Publicado: (2021)

p53 isoforms change p53 paradigm
por: Bourdon, JC
Publicado: (2014)

Asperolide A induces apoptosis and cell cycle arrest of human hepatoma cells with p53-Y220C mutant through p38 mediating phosphorylation of p53 (S33)
por: Lv, Cuiting, et al.
Publicado: (2023)

Recombinant Newcastle disease virus expressing P53 demonstrates promising antitumor efficiency in hepatoma model
por: An, Ying, et al.
Publicado: (2016)

Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells
por: LIU, BIN, et al.
Publicado: (2016)

p53 partial loss-of-function mutations sensitize to chemotherapy
por: Klimovich, Boris, et al.
Publicado: (2021)

Partial p53 reactivation is sufficient to induce cancer regression
por: Klimovich, Boris, et al.
Publicado: (2022)

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis
por: Yue, Xuetian, et al.
Publicado: (2016)

Central role of the p53 pathway in the noncoding-RNA response to oxidative stress
por: Fuschi, Paola, et al.
Publicado: (2017)

Long noncoding RNAs: p53’s secret weapon in the fight against cancer?
por: Dangelmaier, Emily, et al.
Publicado: (2019)

Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis
por: Wang, Chenfeng, et al.
Publicado: (2022)

p53 β-hydroxybutyrylation attenuates p53 activity
por: Liu, Kun, et al.
Publicado: (2019)

Understanding p53 functions through p53 antibodies
por: Sabapathy, Kanaga, et al.
Publicado: (2019)

p53’s Extended Reach: The Mutant p53 Secretome
por: Pavlakis, Evangelos, et al.
Publicado: (2020)

1800MHz Microwave Induces p53 and p53-Mediated Caspase-3 Activation Leading to Cell Apoptosis In Vitro
por: Xing, Fuqiang, et al.
Publicado: (2016)

The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
por: Shen, Jia, et al.
Publicado: (2014)

D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest
por: Aoubala, M, et al.
Publicado: (2010)

Induction of nuclear translocation of mutant cytoplasmic p53 by geranylgeranoic acid in a human hepatoma cell line
por: Iwao, Chieko, et al.
Publicado: (2014)

Silencing of Xeroderma Pigmentosum Group D Gene Promotes Hepatoma Cell Growth by Reducing P53 Expression
por: Ding, Hao, et al.
Publicado: (2018)

OTUD5 Regulates p53 Stability by Deubiquitinating p53
por: Luo, Judong, et al.
Publicado: (2013)

The Δ133p53 Isoforms, Tuners of the p53 Pathway
por: Joruiz, Sebastien M., et al.
Publicado: (2020)

Corrigendum to ‘Understanding p53 functions through p53 antibodies’
por: Sabapathy, Kanaga, et al.
Publicado: (2019)

Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3
por: Aziz, Moammir H., et al.
Publicado: (2011)

YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21(Waf1/Cip1)
por: Sui, Yi, et al.
Publicado: (2019)

Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis
por: Chen, Cheng, et al.
Publicado: (2021)

The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling
por: Gao, Xiao, et al.
Publicado: (2019)

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function
por: Shen, Jia, et al.
Publicado: (2014)

Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53(null) Cell Lines
por: Silden, Elisabeth, et al.
Publicado: (2013)

Tanning with p53
por: Williams, Ruth
Publicado: (2007)

PINTing for p53
por: Shiekhattar, Ramin
Publicado: (2013)

p53 Dysregulation in Breast Cancer: Insights on Mutations in the TP53 Network and p53 Isoform Expression
por: Steffens Reinhardt, Luiza, et al.
Publicado: (2023)

miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop
por: Zhang, Y, et al.
Publicado: (2015)

Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways
por: Lyu, Y, et al.
Publicado: (2017)

Updates on p53: modulation of p53 degradation as a therapeutic approach
por: Dey, A, et al.
Publicado: (2008)

Targeting p53 by small molecule p53 activators in multiple myeloma
por: Saha, Manujendra N, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mgr3earbok122qvpklmrit3k8u