Methods to Make Homogenous Antibody Drug Conjugates

Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homo...

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Detalles Bibliográficos
Autores principales: Kline, Toni, Steiner, Alexander R., Penta, Kalyani, Sato, Aaron K., Hallam, Trevor J., Yin, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Expert Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596908/
https://www.ncbi.nlm.nih.gov/pubmed/25511917
http://dx.doi.org/10.1007/s11095-014-1596-8
Descripción
Sumario:Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homogeneous, defined antibody conjugation. In this review we present the antibody and small molecule chemistries that are currently used and being explored to develop specific, homogenous ADCs.

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