Methods to Make Homogenous Antibody Drug Conjugates

Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homo...

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Detalles Bibliográficos
Autores principales: Kline, Toni, Steiner, Alexander R., Penta, Kalyani, Sato, Aaron K., Hallam, Trevor J., Yin, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Expert Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596908/
https://www.ncbi.nlm.nih.gov/pubmed/25511917
http://dx.doi.org/10.1007/s11095-014-1596-8
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author Kline, Toni
Steiner, Alexander R.
Penta, Kalyani
Sato, Aaron K.
Hallam, Trevor J.
Yin, Gang
author_facet Kline, Toni
Steiner, Alexander R.
Penta, Kalyani
Sato, Aaron K.
Hallam, Trevor J.
Yin, Gang
author_sort Kline, Toni
collection PubMed
description Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homogeneous, defined antibody conjugation. In this review we present the antibody and small molecule chemistries that are currently used and being explored to develop specific, homogenous ADCs.
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spelling pubmed-45969082015-10-13 Methods to Make Homogenous Antibody Drug Conjugates Kline, Toni Steiner, Alexander R. Penta, Kalyani Sato, Aaron K. Hallam, Trevor J. Yin, Gang Pharm Res Expert Review Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homogeneous, defined antibody conjugation. In this review we present the antibody and small molecule chemistries that are currently used and being explored to develop specific, homogenous ADCs. Springer US 2014-12-16 2015 /pmc/articles/PMC4596908/ /pubmed/25511917 http://dx.doi.org/10.1007/s11095-014-1596-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Expert Review
Kline, Toni
Steiner, Alexander R.
Penta, Kalyani
Sato, Aaron K.
Hallam, Trevor J.
Yin, Gang
Methods to Make Homogenous Antibody Drug Conjugates
title Methods to Make Homogenous Antibody Drug Conjugates
title_full Methods to Make Homogenous Antibody Drug Conjugates
title_fullStr Methods to Make Homogenous Antibody Drug Conjugates
title_full_unstemmed Methods to Make Homogenous Antibody Drug Conjugates
title_short Methods to Make Homogenous Antibody Drug Conjugates
title_sort methods to make homogenous antibody drug conjugates
topic Expert Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596908/
https://www.ncbi.nlm.nih.gov/pubmed/25511917
http://dx.doi.org/10.1007/s11095-014-1596-8
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