APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We show that these C-to-U changes lead to the generatio...

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Detalles Bibliográficos
Autores principales: Periyasamy, Manikandan, Patel, Hetal, Lai, Chun-Fui, Nguyen, Van T.M., Nevedomskaya, Ekaterina, Harrod, Alison, Russell, Roslin, Remenyi, Judit, Ochocka, Anna Maria, Thomas, Ross S., Fuller-Pace, Frances, Győrffy, Balázs, Caldas, Carlos, Navaratnam, Naveenan, Carroll, Jason S., Zwart, Wilbert, Coombes, R. Charles, Magnani, Luca, Buluwela, Laki, Ali, Simak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597099/
https://www.ncbi.nlm.nih.gov/pubmed/26411678
http://dx.doi.org/10.1016/j.celrep.2015.08.066

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