Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress

Replication stress activates the Mec1(ATR) and Rad53 kinases. Rad53 phosphorylates nuclear pores to counteract gene gating, thus preventing aberrant transitions at forks approaching transcribed genes. Here, we show that Rrm3 and Pif1, DNA helicases assisting fork progression across pausing sites, ar...

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Detalles Bibliográficos
Autores principales: Rossi, Silvia Emma, Ajazi, Arta, Carotenuto, Walter, Foiani, Marco, Giannattasio, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597105/
https://www.ncbi.nlm.nih.gov/pubmed/26411679
http://dx.doi.org/10.1016/j.celrep.2015.08.073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597105/
https://www.ncbi.nlm.nih.gov/pubmed/26411679
http://dx.doi.org/10.1016/j.celrep.2015.08.073

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