Cargando…

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis remains unknown because this process involves a complex interplay between immune microenvironments and epithelial cells. To ob...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Junyan, Zeng, Hanlin, Liang, Zhongjie, Chen, Limin, Zhang, Liyi, Zhang, Hao, Liu, Hong, Jiang, Hualiang, Shen, Bairong, Huang, Ming, Geng, Meiyu, Spiegel, Sarah, Luo, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597205/ https://www.ncbi.nlm.nih.gov/pubmed/26446703 http://dx.doi.org/10.1038/srep14739

Ejemplares similares

Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents
por: Lin, Chenchu, et al.
Publicado: (2015)

Investigation of the Acetylation Mechanism by GCN5 Histone Acetyltransferase
por: Jiang, Junfeng, et al.
Publicado: (2012)

Lectins, Colitis and Colon Cancer
por: Rhodes, Jonathan M
Publicado: (2000)

Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice
por: Zhang, Xuemei, et al.
Publicado: (2017)

Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
por: Kong, Xiangqian, et al.
Publicado: (2011)

A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacy
por: Zhang, Zongliang, et al.
Publicado: (2023)

A Ferroptosis-Related Gene Signature Identified as a Novel Prognostic Biomarker for Colon Cancer
por: Qi, Xin, et al.
Publicado: (2021)

Combinatorial Detection of Conserved Alteration Patterns for Identifying Cancer Subnetworks
por: Hodzic, Ermin, et al.
Publicado: (2019)

Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice
por: Lin, Rui, et al.
Publicado: (2019)

Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
por: Zhang, Xueli, et al.
Publicado: (2019)

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
por: Szlachta, Karol, et al.
Publicado: (2018)

Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
por: Sharda, Neha, et al.
Publicado: (2021)

Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment
por: Hao, Yang, et al.
Publicado: (2022)

Acute necrotizing colitis due to sigmoid colon cancer
por: Matsunaga, Hiroki, et al.
Publicado: (2014)

Mass-forming ischemic colitis that mimics colon cancer
por: Kim, Ho Seung, et al.
Publicado: (2020)

Ischemic Colitis or Colon Cancer: A Diagnostic Dilemma
por: Khanal, Sneha, et al.
Publicado: (2023)

China's reform of the regulatory system for medical products and its impact
por: Song, Ruilin, et al.
Publicado: (2019)

Identifying neutrophil-associated subtypes in ulcerative colitis and confirming neutrophils promote colitis-associated colorectal cancer
por: Zhang, Chen, et al.
Publicado: (2023)

Meta-analysis and systematic review of the relationship between ulcerative colitis and colon cancer
por: Zhang, Li, et al.
Publicado: (2022)

Identifying combinatorial regulation of transcription factors and binding motifs
por: Kato, Mamoru, et al.
Publicado: (2004)

Identification of Colitis and Cancer in Colon Biopsies by Fourier Transform Infrared Spectroscopy and Chemometrics
por: Li, Xiang, et al.
Publicado: (2012)

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
por: Stolfi, Carmine, et al.
Publicado: (2011)

Hemorrhagic Cytomegalovirus Colitis in a Postoperative Colon Cancer Patient
por: Saito, Motonobu, et al.
Publicado: (2013)

Hemidesmosome integrity protects the colon against colitis and colorectal cancer
por: De Arcangelis, Adèle, et al.
Publicado: (2017)

Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer
por: Pan, Zhaoji, et al.
Publicado: (2023)

Meta-Analysis of Expression Profiling Data Indicates Need for Combinatorial Biomarkers in Pediatric Ulcerative Colitis
por: Li, Xinxiu, et al.
Publicado: (2020)

Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes
por: Quan, Yuan, et al.
Publicado: (2018)

Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer
por: Chellappa, Karthikeyani, et al.
Publicado: (2016)

Computational inference and analysis of genetic regulatory networks via a supervised combinatorial-optimization pattern
por: Tang, Binhua, et al.
Publicado: (2010)

Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis
por: Huang, Yongming, et al.
Publicado: (2022)

Search for Key Genes and Functional Pathways of Ulcerative Colitis to Colon Cancer Based on Bioinformatics
por: Wang, Shengbao, et al.
Publicado: (2022)

Bioactive Equivalence of Combinatorial Components Identified in Screening of an Herbal Medicine
por: Liu, Peng, et al.
Publicado: (2014)

Loss of CHGA Protein as a Potential Biomarker for Colon Cancer Diagnosis: A Study on Biomarker Discovery by Machine Learning and Confirmation by Immunohistochemistry in Colorectal Cancer Tissue Microarrays
por: Zhang, Xueli, et al.
Publicado: (2022)

Colonic cancer induced by 1,2-dimethylhydrazine: promotion by experimental colitis.
por: Chester, J. F., et al.
Publicado: (1989)

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer
por: Hofseth, Lorne J., et al.
Publicado: (2010)

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer
por: Pastille, Eva, et al.
Publicado: (2017)

Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic Review
por: Irrazabal, Thergiory, et al.
Publicado: (2021)

Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease
por: Temby, Michelle, et al.
Publicado: (2023)

Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil
por: Geng, Liyi, et al.
Publicado: (2011)

Key regulators in prostate cancer identified by co-expression module analysis
por: Jiang, Junfeng, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5bb0tit0vhha463jgjcq76cdoj