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Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data

BACKGROUND: Adapter trimming and removal of duplicate reads are common practices in next-generation sequencing pipelines. Sequencing reads ambiguously mapped to repetitive and low complexity regions can also be problematic for accurate assessment of the biological signal, yet their impact on sequenc...

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Detalles Bibliográficos
Autores principales:	Dozmorov, Mikhail G, Adrianto, Indra, Giles, Cory B, Glass, Edmund, Glenn, Stuart B, Montgomery, Courtney, Sivils, Kathy L, Olson, Lorin E, Iwayama, Tomoaki, Freeman, Willard M, Lessard, Christopher J, Wren, Jonathan D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597324/ https://www.ncbi.nlm.nih.gov/pubmed/26423047 http://dx.doi.org/10.1186/1471-2105-16-S13-S10

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