Cargando…

Conformational dynamics of a class C G protein-coupled receptor

G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors in eukaryotes. Crystal structures have provided insight into GPCR interaction with ligands and G-proteins(1,2), but our understanding of the conformational dynamics of activation is incomplete. Metabotropic gluta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vafabakhsh, Reza, Levitz, Joshua, Isacoff, Ehud Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597782/ https://www.ncbi.nlm.nih.gov/pubmed/26258295 http://dx.doi.org/10.1038/nature14679

Ejemplares similares

Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand
por: Broichhagen, Johannes, et al.
Publicado: (2015)

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
por: Berry, Michael H., et al.
Publicado: (2017)

A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors
por: Levitz, Joshua, et al.
Publicado: (2016)

Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
por: Berry, Michael H., et al.
Publicado: (2018)

Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor
por: Donthamsetti, Prashant, et al.
Publicado: (2021)

Conformational pathway provides unique sensitivity to a synaptic mGluR
por: Habrian, Chris H., et al.
Publicado: (2019)

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
por: Vyklicky, Vojtech, et al.
Publicado: (2021)

Delineating the activation mechanism and conformational landscape of a class B G protein-coupled receptor glucagon receptor
por: Wang, Ying, et al.
Publicado: (2022)

Conformational rearrangement during activation of a metabotropic glutamate receptor
por: Liauw, Brandon Wey-Hung, et al.
Publicado: (2021)

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor
por: Louet, Maxime, et al.
Publicado: (2021)

Representation Learning for Class C G Protein-Coupled Receptors Classification
por: Cruz-Barbosa, Raúl, et al.
Publicado: (2018)

Class C G protein-coupled receptors: reviving old couples with new partners
por: Møller, Thor C., et al.
Publicado: (2017)

Conformational dynamics of a G protein–coupled receptor helix 8 in lipid membranes
por: Dijkman, Patricia M., et al.
Publicado: (2020)

Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains
por: Mancinelli, Chiara, et al.
Publicado: (2023)

Molecular Coupling of S4 to a K(+) Channel's Slow Inactivation Gate
por: Loots, Eli, et al.
Publicado: (2000)

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
por: Liauw, Brandon Wey-Hung, et al.
Publicado: (2022)

Allosteric Modulators of Class B G-Protein-Coupled Receptors
por: Hoare, Sam R.J
Publicado: (2007)

Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor
por: Zhao, Li-Hua, et al.
Publicado: (2022)

Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
por: Carpenter, Byron, et al.
Publicado: (2016)

Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET Biosensors
por: Bourque, Kyla, et al.
Publicado: (2017)

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor
por: Gutzeit, Vanessa A, et al.
Publicado: (2019)

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states
por: Heimann, Andrea S., et al.
Publicado: (2017)

Optical Control of Metabotropic Glutamate Receptors
por: Levitz, Joshua, et al.
Publicado: (2013)

The Nature of Functional Features of Different Classes of G-Protein-Coupled Receptors
por: An, Ke, et al.
Publicado: (2022)

Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy
por: Reiner, Andreas, et al.
Publicado: (2014)

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors
por: Martin, Adam L., et al.
Publicado: (2015)

Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states
por: Heimann, Andrea S., et al.
Publicado: (2018)

Effect of Sodium Valproate on the Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin
por: Razzaghi, Neda, et al.
Publicado: (2021)

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
por: Wang, Xudong, et al.
Publicado: (2023)

Allosteric Optical Control of a Class B G‐Protein‐Coupled Receptor
por: Broichhagen, Johannes, et al.
Publicado: (2016)

Optical functionalization of human Class A orphan G-protein-coupled receptors
por: Morri, Maurizio, et al.
Publicado: (2018)

The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors
por: Vu, Oanh, et al.
Publicado: (2021)

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)
por: Barber, David M., et al.
Publicado: (2016)

Structure of the full-length glucagon class B G protein-coupled receptor
por: Zhang, Haonan, et al.
Publicado: (2017)

Designing allosteric modulators for active conformational state of m-glutamate G-protein coupled receptors
por: Omer, Ankur, et al.
Publicado: (2012)

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization
por: Franco, Rafael, et al.
Publicado: (2016)

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work
por: Kleinau, Gunnar, et al.
Publicado: (2017)

Regulation of PP2A(C) Carboxylmethylation and Cellular Localisation by Inhibitory Class G-Protein Coupled Receptors in Cardiomyocytes
por: Longman, Michael R., et al.
Publicado: (2014)

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors
por: Do, Hung N., et al.
Publicado: (2023)

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors
por: Do, Hung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i7kgnpuure72l7rjrs9pmno5n6