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Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

Cystic fibrosis lung disease is characterized by chronic airway infections with the opportunistic pathogen Pseudomonas aeruginosa and severe neutrophilic pulmonary inflammation. P. aeruginosa undergoes extensive genetic adaptation to the cystic fibrosis (CF) lung environment, and adaptive mutations...

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Detalles Bibliográficos
Autores principales:	LaFayette, Shantelle L., Houle, Daniel, Beaudoin, Trevor, Wojewodka, Gabriella, Radzioch, Danuta, Hoffman, Lucas R., Burns, Jane L., Dandekar, Ajai A., Smalley, Nicole E., Chandler, Josephine R., Zlosnik, James E., Speert, David P., Bernier, Joanie, Matouk, Elias, Brochiero, Emmanuelle, Rousseau, Simon, Nguyen, Dao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597794/ https://www.ncbi.nlm.nih.gov/pubmed/26457326 http://dx.doi.org/10.1126/sciadv.1500199

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