Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions

INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways. Both Sulf1 and Sulf2 knockout mice show impairments in brain development and neurite outgro...

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Detalles Bibliográficos
Autores principales: Kalus, Ina, Rohn, Susanne, Puvirajesinghe, Tania M., Guimond, Scott E., Eyckerman-Kölln, Pieter J., ten Dam, Gerdy, van Kuppevelt, Toin H., Turnbull, Jeremy E., Dierks, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598108/
https://www.ncbi.nlm.nih.gov/pubmed/26448642
http://dx.doi.org/10.1371/journal.pone.0139853

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