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Modeling Exon-Specific Bias Distribution Improves the Analysis of RNA-Seq Data

RNA-seq technology has become an important tool for quantifying the gene and transcript expression in transcriptome study. The two major difficulties for the gene and transcript expression quantification are the read mapping ambiguity and the overdispersion of the read distribution along reference s...

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Detalles Bibliográficos
Autores principales: Liu, Xuejun, Zhang, Li, Chen, Songcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598124/
https://www.ncbi.nlm.nih.gov/pubmed/26448625
http://dx.doi.org/10.1371/journal.pone.0140032