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A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children
BACKGROUND: Epistaxis is a common medical problem in pediatric population. Although in most cases it is mild and self-limiting, a proportion of childhood epistaxis is massive, recurrent, or resistant to conventional management. OBJECTIVE: To compare effectiveness of propranolol as a treatment option...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598163/ https://www.ncbi.nlm.nih.gov/pubmed/26457059 http://dx.doi.org/10.2147/AHMT.S84806 |
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author | Ahmed, Ahmed E Abo El-Magd, Essam A Hasan, Gamal M El-Asheer, Osama M |
author_facet | Ahmed, Ahmed E Abo El-Magd, Essam A Hasan, Gamal M El-Asheer, Osama M |
author_sort | Ahmed, Ahmed E |
collection | PubMed |
description | BACKGROUND: Epistaxis is a common medical problem in pediatric population. Although in most cases it is mild and self-limiting, a proportion of childhood epistaxis is massive, recurrent, or resistant to conventional management. OBJECTIVE: To compare effectiveness of propranolol as a treatment option for childhood epistaxis versus conventional silver nitrate cautery. STUDY DESIGN AND METHODOLOGY: This is a prospective interventional comparative study that was carried out during a period of 1 year (January 1, 2013 to December 31, 2013) at Qena University Hospital and Assiut University Children’s Hospital. One hundred children aged 6–12 years who presented with epistaxis to Qena University Hospital and Assiut University Children’s Hospital during the study period and fulfilling the inclusion criteria were included in the study. They were randomly assigned into one of two interventional groups, where 50 children were treated with oral propranolol (propranolol treatment group) and another 50 children were treated with conventional silver nitrate cautery (cauterization treatment group) for their epistaxis. Propranolol was given at a dose of 1.5–2 mg/kg/day (divided into three doses). Patients were followed for 6 months after their discharge for recurrence of epistaxis. RESULTS: Both groups of patients showed minimal recurrent epistaxis with rates of 14% for propranolol treated group and 12% for cauterization group, with no statistically significant difference between both groups. Local pain was found to be more in patients treated with silver nitrate cauterization. CONCLUSION: Treatment of primary epistaxis with propranolol or silver nitrate cautery showed equal rates of recurrence, and local nasal pain was slightly more among silver nitrate cauterization treated group. Propranolol could be a favorable treatment option for patients with primary epistaxis. Further studies that include multiple centers and larger number of patients are recommended for more clarification of the effectiveness of such treatment option. |
format | Online Article Text |
id | pubmed-4598163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45981632015-10-09 A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children Ahmed, Ahmed E Abo El-Magd, Essam A Hasan, Gamal M El-Asheer, Osama M Adolesc Health Med Ther Original Research BACKGROUND: Epistaxis is a common medical problem in pediatric population. Although in most cases it is mild and self-limiting, a proportion of childhood epistaxis is massive, recurrent, or resistant to conventional management. OBJECTIVE: To compare effectiveness of propranolol as a treatment option for childhood epistaxis versus conventional silver nitrate cautery. STUDY DESIGN AND METHODOLOGY: This is a prospective interventional comparative study that was carried out during a period of 1 year (January 1, 2013 to December 31, 2013) at Qena University Hospital and Assiut University Children’s Hospital. One hundred children aged 6–12 years who presented with epistaxis to Qena University Hospital and Assiut University Children’s Hospital during the study period and fulfilling the inclusion criteria were included in the study. They were randomly assigned into one of two interventional groups, where 50 children were treated with oral propranolol (propranolol treatment group) and another 50 children were treated with conventional silver nitrate cautery (cauterization treatment group) for their epistaxis. Propranolol was given at a dose of 1.5–2 mg/kg/day (divided into three doses). Patients were followed for 6 months after their discharge for recurrence of epistaxis. RESULTS: Both groups of patients showed minimal recurrent epistaxis with rates of 14% for propranolol treated group and 12% for cauterization group, with no statistically significant difference between both groups. Local pain was found to be more in patients treated with silver nitrate cauterization. CONCLUSION: Treatment of primary epistaxis with propranolol or silver nitrate cautery showed equal rates of recurrence, and local nasal pain was slightly more among silver nitrate cauterization treated group. Propranolol could be a favorable treatment option for patients with primary epistaxis. Further studies that include multiple centers and larger number of patients are recommended for more clarification of the effectiveness of such treatment option. Dove Medical Press 2015-09-30 /pmc/articles/PMC4598163/ /pubmed/26457059 http://dx.doi.org/10.2147/AHMT.S84806 Text en © 2015 Ahmed et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ahmed, Ahmed E Abo El-Magd, Essam A Hasan, Gamal M El-Asheer, Osama M A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
title | A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
title_full | A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
title_fullStr | A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
title_full_unstemmed | A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
title_short | A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
title_sort | comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598163/ https://www.ncbi.nlm.nih.gov/pubmed/26457059 http://dx.doi.org/10.2147/AHMT.S84806 |
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