Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model

BACKGROUND: Silver nanoparticles (Ag-NPs) can enter the brain and induce neurotoxicity. However, the toxicity of Ag-NPs on the blood–brain barrier (BBB) and the underlying mechanism(s) of action on the BBB and the brain are not well understood. METHOD: To investigate Ag-NP suspension (Ag-NPS)-induce...

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Detalles Bibliográficos
Autores principales: Xu, Liming, Dan, Mo, Shao, Anliang, Cheng, Xiang, Zhang, Cuiping, Yokel, Robert A, Takemura, Taro, Hanagata, Nobutaka, Niwa, Masami, Watanabe, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598217/
https://www.ncbi.nlm.nih.gov/pubmed/26491287
http://dx.doi.org/10.2147/IJN.S85265

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