HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

Given the wide differences in HIV-1 viral load (VL) setpoint across subjects as opposed to fairly stable VL over time within an infected individual, it is important to identify host and viral characteristics that affect VL setpoint. While recently-infected individuals with multiple phylogenetically-...

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Detalles Bibliográficos
Autores principales: Janes, Holly, Herbeck, Joshua T., Tovanabutra, Sodsai, Thomas, Rasmi, Frahm, Nicole, Duerr, Ann, Hural, John, Corey, Lawrence, Self, Steve G., Buchbinder, Susan P., McElrath, M. Juliana, O'Connell, Robert J., Paris, Robert M., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Pitisuttihum, Punnee, Kaewkungwal, Jaranit, Robb, Merlin L., Michael, Nelson L., Mullins, James I., Kim, Jerome H., Gilbert, Peter B., Rolland, Morgane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598284/
https://www.ncbi.nlm.nih.gov/pubmed/26322580
http://dx.doi.org/10.1038/nm.3932
Descripción
Sumario:Given the wide differences in HIV-1 viral load (VL) setpoint across subjects as opposed to fairly stable VL over time within an infected individual, it is important to identify host and viral characteristics that affect VL setpoint. While recently-infected individuals with multiple phylogenetically-linked HIV-1 founder variants represent a minority of HIV-1 infections, we found in two different cohorts that more diverse HIV-1 populations in early infection were associated with significantly higher VL one year after HIV-1 diagnosis.

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