HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

Given the wide differences in HIV-1 viral load (VL) setpoint across subjects as opposed to fairly stable VL over time within an infected individual, it is important to identify host and viral characteristics that affect VL setpoint. While recently-infected individuals with multiple phylogenetically-...

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Autores principales: Janes, Holly, Herbeck, Joshua T., Tovanabutra, Sodsai, Thomas, Rasmi, Frahm, Nicole, Duerr, Ann, Hural, John, Corey, Lawrence, Self, Steve G., Buchbinder, Susan P., McElrath, M. Juliana, O'Connell, Robert J., Paris, Robert M., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Pitisuttihum, Punnee, Kaewkungwal, Jaranit, Robb, Merlin L., Michael, Nelson L., Mullins, James I., Kim, Jerome H., Gilbert, Peter B., Rolland, Morgane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598284/
https://www.ncbi.nlm.nih.gov/pubmed/26322580
http://dx.doi.org/10.1038/nm.3932
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author Janes, Holly
Herbeck, Joshua T.
Tovanabutra, Sodsai
Thomas, Rasmi
Frahm, Nicole
Duerr, Ann
Hural, John
Corey, Lawrence
Self, Steve G.
Buchbinder, Susan P.
McElrath, M. Juliana
O'Connell, Robert J.
Paris, Robert M.
Rerks-Ngarm, Supachai
Nitayaphan, Sorachai
Pitisuttihum, Punnee
Kaewkungwal, Jaranit
Robb, Merlin L.
Michael, Nelson L.
Mullins, James I.
Kim, Jerome H.
Gilbert, Peter B.
Rolland, Morgane
author_facet Janes, Holly
Herbeck, Joshua T.
Tovanabutra, Sodsai
Thomas, Rasmi
Frahm, Nicole
Duerr, Ann
Hural, John
Corey, Lawrence
Self, Steve G.
Buchbinder, Susan P.
McElrath, M. Juliana
O'Connell, Robert J.
Paris, Robert M.
Rerks-Ngarm, Supachai
Nitayaphan, Sorachai
Pitisuttihum, Punnee
Kaewkungwal, Jaranit
Robb, Merlin L.
Michael, Nelson L.
Mullins, James I.
Kim, Jerome H.
Gilbert, Peter B.
Rolland, Morgane
author_sort Janes, Holly
collection PubMed
description Given the wide differences in HIV-1 viral load (VL) setpoint across subjects as opposed to fairly stable VL over time within an infected individual, it is important to identify host and viral characteristics that affect VL setpoint. While recently-infected individuals with multiple phylogenetically-linked HIV-1 founder variants represent a minority of HIV-1 infections, we found in two different cohorts that more diverse HIV-1 populations in early infection were associated with significantly higher VL one year after HIV-1 diagnosis.
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spelling pubmed-45982842016-04-01 HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders Janes, Holly Herbeck, Joshua T. Tovanabutra, Sodsai Thomas, Rasmi Frahm, Nicole Duerr, Ann Hural, John Corey, Lawrence Self, Steve G. Buchbinder, Susan P. McElrath, M. Juliana O'Connell, Robert J. Paris, Robert M. Rerks-Ngarm, Supachai Nitayaphan, Sorachai Pitisuttihum, Punnee Kaewkungwal, Jaranit Robb, Merlin L. Michael, Nelson L. Mullins, James I. Kim, Jerome H. Gilbert, Peter B. Rolland, Morgane Nat Med Article Given the wide differences in HIV-1 viral load (VL) setpoint across subjects as opposed to fairly stable VL over time within an infected individual, it is important to identify host and viral characteristics that affect VL setpoint. While recently-infected individuals with multiple phylogenetically-linked HIV-1 founder variants represent a minority of HIV-1 infections, we found in two different cohorts that more diverse HIV-1 populations in early infection were associated with significantly higher VL one year after HIV-1 diagnosis. 2015-08-31 2015-10 /pmc/articles/PMC4598284/ /pubmed/26322580 http://dx.doi.org/10.1038/nm.3932 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Janes, Holly
Herbeck, Joshua T.
Tovanabutra, Sodsai
Thomas, Rasmi
Frahm, Nicole
Duerr, Ann
Hural, John
Corey, Lawrence
Self, Steve G.
Buchbinder, Susan P.
McElrath, M. Juliana
O'Connell, Robert J.
Paris, Robert M.
Rerks-Ngarm, Supachai
Nitayaphan, Sorachai
Pitisuttihum, Punnee
Kaewkungwal, Jaranit
Robb, Merlin L.
Michael, Nelson L.
Mullins, James I.
Kim, Jerome H.
Gilbert, Peter B.
Rolland, Morgane
HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
title HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
title_full HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
title_fullStr HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
title_full_unstemmed HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
title_short HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
title_sort hiv-1 infections with multiple founders are associated with higher viral loads than infections with single founders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598284/
https://www.ncbi.nlm.nih.gov/pubmed/26322580
http://dx.doi.org/10.1038/nm.3932
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