Critical Role of Acetylation in Tau-Mediated Neurodegeneration and Cognitive Deficits

Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD), are neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports soluble tau species as the major toxic species. How soluble tau accumulates and how it causes neurodegeneration remains unclear....

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Detalles Bibliográficos
Autores principales: Min, Sang-Won, Chen, Xu, Tracy, Tara E, Li, Yaqiao, Zhou, Yungui, Wang, Chao, Shirakawa, Kotaro, Minami, S. Sakura, Defensor, Erwin, Mok, Sue Ann, Sohn, Peter Dongmin, Schilling, Birgit, Cong, Xin, Ellerby, Lisa, Gibson, Bradford W., Johnson, Jeffrey, Krogan, Nevan, Shamloo, Mehrdad, Gestwicki, Jason, Masliah, Eliezer, Verdin, Eric, Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598295/
https://www.ncbi.nlm.nih.gov/pubmed/26390242
http://dx.doi.org/10.1038/nm.3951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598295/
https://www.ncbi.nlm.nih.gov/pubmed/26390242
http://dx.doi.org/10.1038/nm.3951

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