Astrocyte matricellular proteins that control excitatory synaptogenesis are regulated by inflammatory cytokines and correlate with paralysis severity during experimental autoimmune encephalomyelitis

The matricellular proteins, secreted protein acidic and rich in cysteine (SPARC) and SPARC-like 1 (SPARCL1), are produced by astrocytes and control excitatory synaptogenesis in the central nervous system. While SPARCL1 directly promotes excitatory synapse formation in vitro and in the developing ner...

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Detalles Bibliográficos
Autores principales: Blakely, Pennelope K., Hussain, Shabbir, Carlin, Lindsey E., Irani, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598482/
https://www.ncbi.nlm.nih.gov/pubmed/26500475
http://dx.doi.org/10.3389/fnins.2015.00344

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