Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation

During mitosis, Bub1 kinase phosphorylates histone H2A-T120 to promote centromere sister chromatid cohesion through recruitment of shugoshin (Sgo) proteins. The regulation and dynamics of H2A-T120 phosphorylation are poorly understood. Using quantitative phosphoproteomics we show that Bub1 is autoph...

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Detalles Bibliográficos
Autores principales: Asghar, Adeel, Lajeunesse, Audrey, Dulla, Kalyan, Combes, Guillaume, Thebault, Philippe, Nigg, Erich A., Elowe, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598568/
https://www.ncbi.nlm.nih.gov/pubmed/26399325
http://dx.doi.org/10.1038/ncomms9364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598568/
https://www.ncbi.nlm.nih.gov/pubmed/26399325
http://dx.doi.org/10.1038/ncomms9364

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