Cargando…

A New Role for Browning as a Redox and Stress Adaptive Mechanism?

The worldwide epidemic of obesity and metabolic disorders is focusing the attention of the scientific community on white adipose tissue (WAT) and its biology. This tissue is characterized not only by its capability to change in size and shape but also by its heterogeneity and versatility. WAT can be...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeanson, Yannick, Carrière, Audrey, Casteilla, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598589/
https://www.ncbi.nlm.nih.gov/pubmed/26500607
http://dx.doi.org/10.3389/fendo.2015.00158
_version_ 1782394094004207616
author Jeanson, Yannick
Carrière, Audrey
Casteilla, Louis
author_facet Jeanson, Yannick
Carrière, Audrey
Casteilla, Louis
author_sort Jeanson, Yannick
collection PubMed
description The worldwide epidemic of obesity and metabolic disorders is focusing the attention of the scientific community on white adipose tissue (WAT) and its biology. This tissue is characterized not only by its capability to change in size and shape but also by its heterogeneity and versatility. WAT can be converted into brown fat-like tissue according to different physiological and pathophysiological situations. The expression of uncoupling protein-1 in brown-like adipocytes changes their function from energy storage to energy dissipation. This plasticity, named browning, was recently rediscovered and convergent recent accounts, including in humans, have revived the idea of using these oxidative cells to fight against metabolic diseases. Furthermore, recent reports suggest that, beside the increased energy dissipation and thermogenesis that may have adverse effects in situations such as cancer-associated cachexia and massive burns, browning could be also considered as an adaptive stress response to high redox pressure and to major stress that could help to maintain tissue homeostasis and integrity. The aim of this review is to summarize the current knowledge concerning brown adipocytes and the browning process and also to explore unexpected putative role(s) for these cells. While it is important to find new browning inducers to limit energy stores and metabolic diseases, it also appears crucial to develop new browning inhibitors to limit adverse energy dissipation in wasting-associated syndromes.
format Online
Article
Text
id pubmed-4598589
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-45985892015-10-23 A New Role for Browning as a Redox and Stress Adaptive Mechanism? Jeanson, Yannick Carrière, Audrey Casteilla, Louis Front Endocrinol (Lausanne) Endocrinology The worldwide epidemic of obesity and metabolic disorders is focusing the attention of the scientific community on white adipose tissue (WAT) and its biology. This tissue is characterized not only by its capability to change in size and shape but also by its heterogeneity and versatility. WAT can be converted into brown fat-like tissue according to different physiological and pathophysiological situations. The expression of uncoupling protein-1 in brown-like adipocytes changes their function from energy storage to energy dissipation. This plasticity, named browning, was recently rediscovered and convergent recent accounts, including in humans, have revived the idea of using these oxidative cells to fight against metabolic diseases. Furthermore, recent reports suggest that, beside the increased energy dissipation and thermogenesis that may have adverse effects in situations such as cancer-associated cachexia and massive burns, browning could be also considered as an adaptive stress response to high redox pressure and to major stress that could help to maintain tissue homeostasis and integrity. The aim of this review is to summarize the current knowledge concerning brown adipocytes and the browning process and also to explore unexpected putative role(s) for these cells. While it is important to find new browning inducers to limit energy stores and metabolic diseases, it also appears crucial to develop new browning inhibitors to limit adverse energy dissipation in wasting-associated syndromes. Frontiers Media S.A. 2015-10-09 /pmc/articles/PMC4598589/ /pubmed/26500607 http://dx.doi.org/10.3389/fendo.2015.00158 Text en Copyright © 2015 Jeanson, Carrière and Casteilla. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Jeanson, Yannick
Carrière, Audrey
Casteilla, Louis
A New Role for Browning as a Redox and Stress Adaptive Mechanism?
title A New Role for Browning as a Redox and Stress Adaptive Mechanism?
title_full A New Role for Browning as a Redox and Stress Adaptive Mechanism?
title_fullStr A New Role for Browning as a Redox and Stress Adaptive Mechanism?
title_full_unstemmed A New Role for Browning as a Redox and Stress Adaptive Mechanism?
title_short A New Role for Browning as a Redox and Stress Adaptive Mechanism?
title_sort new role for browning as a redox and stress adaptive mechanism?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598589/
https://www.ncbi.nlm.nih.gov/pubmed/26500607
http://dx.doi.org/10.3389/fendo.2015.00158
work_keys_str_mv AT jeansonyannick anewroleforbrowningasaredoxandstressadaptivemechanism
AT carriereaudrey anewroleforbrowningasaredoxandstressadaptivemechanism
AT casteillalouis anewroleforbrowningasaredoxandstressadaptivemechanism
AT jeansonyannick newroleforbrowningasaredoxandstressadaptivemechanism
AT carriereaudrey newroleforbrowningasaredoxandstressadaptivemechanism
AT casteillalouis newroleforbrowningasaredoxandstressadaptivemechanism