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Sox9 Expression in Canine Epithelial Skin Tumors

Sox9 is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from...

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Autores principales: Fantinato, E., Milani, L., Sironi, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598595/
https://www.ncbi.nlm.nih.gov/pubmed/26428883
http://dx.doi.org/10.4081/ejh.2015.2514
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author Fantinato, E.
Milani, L.
Sironi, G.
author_facet Fantinato, E.
Milani, L.
Sironi, G.
author_sort Fantinato, E.
collection PubMed
description Sox9 is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from eleven different types of canine skin neoplasms (squamous papilloma, squamous cell carcinoma, infundibular keratinizing acanthoma, inferior tricholemmoma, isthmic tricholemmoma, trichoblastoma, trichoepithelioma, malignant trichoepithelioma, pilomatricoma, subungual keratoacanthoma, subungual squamous cell carcinoma) were immunohistochemically stained and evaluated for Sox9 with the aim to correlate tumor phenotype with molecular characteristics that may help to better define tumor development, contribute to its diagnosis and clinical management. Keratoacanthoma excluded, all the skin neoplasms examined showed a variable positivity to Sox9, especially in the basal layers, but with major intensity in neoplasms developing from the bulge region of the hair follicle, as trichoblastoma. According to our results, Sox9 could be employed as a stem cell marker to better assess the role of stem cells in canine epidermal and follicular tumors.
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spelling pubmed-45985952015-10-23 Sox9 Expression in Canine Epithelial Skin Tumors Fantinato, E. Milani, L. Sironi, G. Eur J Histochem Brief Report Sox9 is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from eleven different types of canine skin neoplasms (squamous papilloma, squamous cell carcinoma, infundibular keratinizing acanthoma, inferior tricholemmoma, isthmic tricholemmoma, trichoblastoma, trichoepithelioma, malignant trichoepithelioma, pilomatricoma, subungual keratoacanthoma, subungual squamous cell carcinoma) were immunohistochemically stained and evaluated for Sox9 with the aim to correlate tumor phenotype with molecular characteristics that may help to better define tumor development, contribute to its diagnosis and clinical management. Keratoacanthoma excluded, all the skin neoplasms examined showed a variable positivity to Sox9, especially in the basal layers, but with major intensity in neoplasms developing from the bulge region of the hair follicle, as trichoblastoma. According to our results, Sox9 could be employed as a stem cell marker to better assess the role of stem cells in canine epidermal and follicular tumors. PAGEPress Publications, Pavia, Italy 2015-07-09 /pmc/articles/PMC4598595/ /pubmed/26428883 http://dx.doi.org/10.4081/ejh.2015.2514 Text en ©Copyright E. Fantinato, et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Fantinato, E.
Milani, L.
Sironi, G.
Sox9 Expression in Canine Epithelial Skin Tumors
title Sox9 Expression in Canine Epithelial Skin Tumors
title_full Sox9 Expression in Canine Epithelial Skin Tumors
title_fullStr Sox9 Expression in Canine Epithelial Skin Tumors
title_full_unstemmed Sox9 Expression in Canine Epithelial Skin Tumors
title_short Sox9 Expression in Canine Epithelial Skin Tumors
title_sort sox9 expression in canine epithelial skin tumors
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598595/
https://www.ncbi.nlm.nih.gov/pubmed/26428883
http://dx.doi.org/10.4081/ejh.2015.2514
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