Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson’s Disease Brains Are Differentially Generated in Mammalian Cell Models

Misfolding and aggregation of α-synuclein into toxic soluble oligomeric α-synuclein aggregates has been strongly correlated with the pathogenesis of Parkinson’s disease (PD). Here, we show that two different morphologically distinct oligomeric α-synuclein aggregates are present in human post-mortem...

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Detalles Bibliográficos
Autores principales: Xin, Wei, Emadi, Sharareh, Williams, Stephanie, Liu, Qiang, Schulz, Philip, He, Ping, Alam, Now Bahar, Wu, Jie, Sierks, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598768/
https://www.ncbi.nlm.nih.gov/pubmed/26287258
http://dx.doi.org/10.3390/biom5031634

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