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Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels

All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential dis...

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Detalles Bibliográficos
Autores principales: Hermann, Anton, Sitdikova, Guzel F., Weiger, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598779/
https://www.ncbi.nlm.nih.gov/pubmed/26287261
http://dx.doi.org/10.3390/biom5031870
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author Hermann, Anton
Sitdikova, Guzel F.
Weiger, Thomas M.
author_facet Hermann, Anton
Sitdikova, Guzel F.
Weiger, Thomas M.
author_sort Hermann, Anton
collection PubMed
description All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK) channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences.
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spelling pubmed-45987792015-10-15 Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels Hermann, Anton Sitdikova, Guzel F. Weiger, Thomas M. Biomolecules Review All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK) channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences. MDPI 2015-08-17 /pmc/articles/PMC4598779/ /pubmed/26287261 http://dx.doi.org/10.3390/biom5031870 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hermann, Anton
Sitdikova, Guzel F.
Weiger, Thomas M.
Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
title Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
title_full Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
title_fullStr Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
title_full_unstemmed Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
title_short Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
title_sort oxidative stress and maxi calcium-activated potassium (bk) channels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598779/
https://www.ncbi.nlm.nih.gov/pubmed/26287261
http://dx.doi.org/10.3390/biom5031870
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