Macrophage Expression of Inflammatory Genes in Response to EMCV Infection

The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes an...

Descripción completa

Detalles Bibliográficos
Autores principales: Shaheen, Zachary R., Corbett, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598781/
https://www.ncbi.nlm.nih.gov/pubmed/26295266
http://dx.doi.org/10.3390/biom5031938
_version_ 1782394130626772992
author Shaheen, Zachary R.
Corbett, John A.
author_facet Shaheen, Zachary R.
Corbett, John A.
author_sort Shaheen, Zachary R.
collection PubMed
description The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes and the roles that these inflammatory mediators contribute to host defense against viral pathogens will be discussed. Specific focus will be on the role of the chemokine receptor CCR5, as a signaling receptor controlling the activation of pathways leading to virus-induced inflammatory gene expression.
format Online
Article
Text
id pubmed-4598781
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-45987812015-10-15 Macrophage Expression of Inflammatory Genes in Response to EMCV Infection Shaheen, Zachary R. Corbett, John A. Biomolecules Review The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes and the roles that these inflammatory mediators contribute to host defense against viral pathogens will be discussed. Specific focus will be on the role of the chemokine receptor CCR5, as a signaling receptor controlling the activation of pathways leading to virus-induced inflammatory gene expression. MDPI 2015-08-18 /pmc/articles/PMC4598781/ /pubmed/26295266 http://dx.doi.org/10.3390/biom5031938 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shaheen, Zachary R.
Corbett, John A.
Macrophage Expression of Inflammatory Genes in Response to EMCV Infection
title Macrophage Expression of Inflammatory Genes in Response to EMCV Infection
title_full Macrophage Expression of Inflammatory Genes in Response to EMCV Infection
title_fullStr Macrophage Expression of Inflammatory Genes in Response to EMCV Infection
title_full_unstemmed Macrophage Expression of Inflammatory Genes in Response to EMCV Infection
title_short Macrophage Expression of Inflammatory Genes in Response to EMCV Infection
title_sort macrophage expression of inflammatory genes in response to emcv infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598781/
https://www.ncbi.nlm.nih.gov/pubmed/26295266
http://dx.doi.org/10.3390/biom5031938
work_keys_str_mv AT shaheenzacharyr macrophageexpressionofinflammatorygenesinresponsetoemcvinfection
AT corbettjohna macrophageexpressionofinflammatorygenesinresponsetoemcvinfection

Ejemplares similares