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Dental extraction in patients receiving dual antiplatelet therapy

BACKGROUND: Dual anti platelet therapy consists of administering antiplatelet (antiaggregant) drugs (clopidogrel and aspirin) to prevent thrombotic processes, as a preventative measure in patients with acute coronary disease, or in patients subjected to percutaneous coronary intervention. OBJECTIVES...

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Autores principales: Sánchez-Palomino, Paulino, Sánchez-Cobo, Paulino, Rodriguez-Archilla, Alberto, González-Jaranay, Maximino, Moreu, Gerardo, Calvo-Guirado, José-Luis, Peñarrocha-Diago, Miguel, Gómez-Moreno, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598932/
https://www.ncbi.nlm.nih.gov/pubmed/26241454
http://dx.doi.org/10.4317/medoral.20510
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author Sánchez-Palomino, Paulino
Sánchez-Cobo, Paulino
Rodriguez-Archilla, Alberto
González-Jaranay, Maximino
Moreu, Gerardo
Calvo-Guirado, José-Luis
Peñarrocha-Diago, Miguel
Gómez-Moreno, Gerardo
author_facet Sánchez-Palomino, Paulino
Sánchez-Cobo, Paulino
Rodriguez-Archilla, Alberto
González-Jaranay, Maximino
Moreu, Gerardo
Calvo-Guirado, José-Luis
Peñarrocha-Diago, Miguel
Gómez-Moreno, Gerardo
author_sort Sánchez-Palomino, Paulino
collection PubMed
description BACKGROUND: Dual anti platelet therapy consists of administering antiplatelet (antiaggregant) drugs (clopidogrel and aspirin) to prevent thrombotic processes, as a preventative measure in patients with acute coronary disease, or in patients subjected to percutaneous coronary intervention. OBJECTIVES: The purpose of this study was to evaluate the efficacy of a protocol for performing dental extraction in patients receiving dual anti platelet therapy. MATERIAL AND METHODS: Thirty-two patients undergoing dental extractions were included in the study. The variables evaluated were: collagen-epinephrine fraction, collagen- adenosine diphosphate fraction, surgical surface, post-surgical measures, and adverse effects. Alveolar sutures and gauzes impregnated with an antifibrinolytic agent (tranexamic acid), which the patient pressed in place for 30 minutes, were applied to all patients as post-surgical measures. Descriptive statistics were calculated and analyzed with Student’s t-test to compare pairs of quantitative variables; simple regression analysis was performed using Pearson’s correlation coefficient. Statistical significance was set at p<0.05. RESULTS: Collagen/epinephrine fraction was 264.53±55.624 seconds with a range of 135 to 300 seconds, and collagen/ADP fraction was 119.41±44.216 seconds, both values being higher than normal. As a result of the post-surgical measures taken, no patients presented postoperative bleeding, hematoma or infection. CONCLUSIONS: Dental extraction was safe for patients receiving dual anti-platelet therapy when using sutures and gauze impregnated with tranexamic acid, which the patient pressed in place for 30 minutes. Key words: Aspirin, clopidogrel, tranexamic acid, dental extraction, platelet function.
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spelling pubmed-45989322015-10-15 Dental extraction in patients receiving dual antiplatelet therapy Sánchez-Palomino, Paulino Sánchez-Cobo, Paulino Rodriguez-Archilla, Alberto González-Jaranay, Maximino Moreu, Gerardo Calvo-Guirado, José-Luis Peñarrocha-Diago, Miguel Gómez-Moreno, Gerardo Med Oral Patol Oral Cir Bucal Research BACKGROUND: Dual anti platelet therapy consists of administering antiplatelet (antiaggregant) drugs (clopidogrel and aspirin) to prevent thrombotic processes, as a preventative measure in patients with acute coronary disease, or in patients subjected to percutaneous coronary intervention. OBJECTIVES: The purpose of this study was to evaluate the efficacy of a protocol for performing dental extraction in patients receiving dual anti platelet therapy. MATERIAL AND METHODS: Thirty-two patients undergoing dental extractions were included in the study. The variables evaluated were: collagen-epinephrine fraction, collagen- adenosine diphosphate fraction, surgical surface, post-surgical measures, and adverse effects. Alveolar sutures and gauzes impregnated with an antifibrinolytic agent (tranexamic acid), which the patient pressed in place for 30 minutes, were applied to all patients as post-surgical measures. Descriptive statistics were calculated and analyzed with Student’s t-test to compare pairs of quantitative variables; simple regression analysis was performed using Pearson’s correlation coefficient. Statistical significance was set at p<0.05. RESULTS: Collagen/epinephrine fraction was 264.53±55.624 seconds with a range of 135 to 300 seconds, and collagen/ADP fraction was 119.41±44.216 seconds, both values being higher than normal. As a result of the post-surgical measures taken, no patients presented postoperative bleeding, hematoma or infection. CONCLUSIONS: Dental extraction was safe for patients receiving dual anti-platelet therapy when using sutures and gauze impregnated with tranexamic acid, which the patient pressed in place for 30 minutes. Key words: Aspirin, clopidogrel, tranexamic acid, dental extraction, platelet function. Medicina Oral S.L. 2015-09 2015-08-04 /pmc/articles/PMC4598932/ /pubmed/26241454 http://dx.doi.org/10.4317/medoral.20510 Text en Copyright: © 2015 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Sánchez-Palomino, Paulino
Sánchez-Cobo, Paulino
Rodriguez-Archilla, Alberto
González-Jaranay, Maximino
Moreu, Gerardo
Calvo-Guirado, José-Luis
Peñarrocha-Diago, Miguel
Gómez-Moreno, Gerardo
Dental extraction in patients receiving dual antiplatelet therapy
title Dental extraction in patients receiving dual antiplatelet therapy
title_full Dental extraction in patients receiving dual antiplatelet therapy
title_fullStr Dental extraction in patients receiving dual antiplatelet therapy
title_full_unstemmed Dental extraction in patients receiving dual antiplatelet therapy
title_short Dental extraction in patients receiving dual antiplatelet therapy
title_sort dental extraction in patients receiving dual antiplatelet therapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598932/
https://www.ncbi.nlm.nih.gov/pubmed/26241454
http://dx.doi.org/10.4317/medoral.20510
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