Analgesic effects of NB001 on mouse models of arthralgia

Our previous studies have demonstrated the critical roles of calcium-stimulated adenylyl cyclase 1 (AC1) in the central nervous system in chronic pain. In the present study, we examined the analgesic effects of NB001, a selective inhibitor of AC1, on animal models of ankle joint arthritis and knee j...

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Autores principales: Tian, Zhen, Wang, Dong-sheng, Wang, Xin-shang, Tian, Jiao, Han, Jing, Guo, Yan-yan, Feng, Bin, Zhang, Nan, Zhao, Ming-gao, Liu, Shui-bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599030/
https://www.ncbi.nlm.nih.gov/pubmed/26452469
http://dx.doi.org/10.1186/s13041-015-0151-9
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author Tian, Zhen
Wang, Dong-sheng
Wang, Xin-shang
Tian, Jiao
Han, Jing
Guo, Yan-yan
Feng, Bin
Zhang, Nan
Zhao, Ming-gao
Liu, Shui-bing
author_facet Tian, Zhen
Wang, Dong-sheng
Wang, Xin-shang
Tian, Jiao
Han, Jing
Guo, Yan-yan
Feng, Bin
Zhang, Nan
Zhao, Ming-gao
Liu, Shui-bing
author_sort Tian, Zhen
collection PubMed
description Our previous studies have demonstrated the critical roles of calcium-stimulated adenylyl cyclase 1 (AC1) in the central nervous system in chronic pain. In the present study, we examined the analgesic effects of NB001, a selective inhibitor of AC1, on animal models of ankle joint arthritis and knee joint arthritis induced by complete Freund’s adjuvant injection. NB001 treatment had no effect on joint edema, stiffness, and joint destruction. Furthermore, the treatment failed to attenuate the disease progression of arthritis. However, NB001 treatment (3 mg/kg) significantly weakened joint pain-related behavior in the mouse models of ankle joint arthritis and knee joint arthritis. Results indicated that NB001 exhibited an analgesic effect on the animal models of arthritis but was not caused by anti-inflammatory activities.
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spelling pubmed-45990302015-10-09 Analgesic effects of NB001 on mouse models of arthralgia Tian, Zhen Wang, Dong-sheng Wang, Xin-shang Tian, Jiao Han, Jing Guo, Yan-yan Feng, Bin Zhang, Nan Zhao, Ming-gao Liu, Shui-bing Mol Brain Research Our previous studies have demonstrated the critical roles of calcium-stimulated adenylyl cyclase 1 (AC1) in the central nervous system in chronic pain. In the present study, we examined the analgesic effects of NB001, a selective inhibitor of AC1, on animal models of ankle joint arthritis and knee joint arthritis induced by complete Freund’s adjuvant injection. NB001 treatment had no effect on joint edema, stiffness, and joint destruction. Furthermore, the treatment failed to attenuate the disease progression of arthritis. However, NB001 treatment (3 mg/kg) significantly weakened joint pain-related behavior in the mouse models of ankle joint arthritis and knee joint arthritis. Results indicated that NB001 exhibited an analgesic effect on the animal models of arthritis but was not caused by anti-inflammatory activities. BioMed Central 2015-10-09 /pmc/articles/PMC4599030/ /pubmed/26452469 http://dx.doi.org/10.1186/s13041-015-0151-9 Text en © Tian et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Tian, Zhen
Wang, Dong-sheng
Wang, Xin-shang
Tian, Jiao
Han, Jing
Guo, Yan-yan
Feng, Bin
Zhang, Nan
Zhao, Ming-gao
Liu, Shui-bing
Analgesic effects of NB001 on mouse models of arthralgia
title Analgesic effects of NB001 on mouse models of arthralgia
title_full Analgesic effects of NB001 on mouse models of arthralgia
title_fullStr Analgesic effects of NB001 on mouse models of arthralgia
title_full_unstemmed Analgesic effects of NB001 on mouse models of arthralgia
title_short Analgesic effects of NB001 on mouse models of arthralgia
title_sort analgesic effects of nb001 on mouse models of arthralgia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599030/
https://www.ncbi.nlm.nih.gov/pubmed/26452469
http://dx.doi.org/10.1186/s13041-015-0151-9
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