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Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients
BACKGROUND: Neutrophil to lymphocyte ratio (NLR) has recently been reported to be a poor prognostic indicator in lung cancer. However, the prognostic value of the NLR in patients with lung cancer still remains controversial. We performed a meta-analysis to evaluate the prognostic value of NLR in pat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599071/ https://www.ncbi.nlm.nih.gov/pubmed/26491346 http://dx.doi.org/10.2147/OTT.S90875 |
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author | Zhao, Qing-Tao Yang, Yong Xu, Shun Zhang, Xiao-Peng Wang, Hui-En Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen |
author_facet | Zhao, Qing-Tao Yang, Yong Xu, Shun Zhang, Xiao-Peng Wang, Hui-En Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen |
author_sort | Zhao, Qing-Tao |
collection | PubMed |
description | BACKGROUND: Neutrophil to lymphocyte ratio (NLR) has recently been reported to be a poor prognostic indicator in lung cancer. However, the prognostic value of the NLR in patients with lung cancer still remains controversial. We performed a meta-analysis to evaluate the prognostic value of NLR in patients with lung cancer. METHODS: We performed a comprehensive literature search in PubMed, Ovid, the Cochrane Library, and Web of Science databases in May 2015. Studies were assessed for quality using the Newcastle–Ottawa Scale. RESULTS: Twenty-two studies with a total of 7,054 patients were included in this meta-analysis. The meta-analysis was performed to generate combined hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS). Our analysis results indicated that high NLR predicted poorer OS (HR, 1.51; 95% confidence interval [CI], 1.33–1.71; P<0.001) and PFS (HR, 1.33; 95% CI, 1.07–1.67; P=0.012) in patients with lung cancer. High NLR was also associated with poor OS in lung cancer treated by surgical resection (HR, 1.59; 95% CI, 1.26–1.99; P<0.001) and chemotherapy (HR, 1.15; 95% CI, 1.08–1.22; P<0.001). In addition, NLR cut-off value =5 (HR, 1.57; 95% CI, 1.16–2.12; P=0.003) and NLR cut-off value <5 (HR, 1.47; 95% CI, 1.28–1.69; P<0.001). CONCLUSION: This meta-analysis result suggested that NLR should have significant predictive ability for estimating OS and PFS in patients with lung cancer and may be as a significant biomarker in the prognosis of lung cancer. |
format | Online Article Text |
id | pubmed-4599071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45990712015-10-21 Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients Zhao, Qing-Tao Yang, Yong Xu, Shun Zhang, Xiao-Peng Wang, Hui-En Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen Onco Targets Ther Original Research BACKGROUND: Neutrophil to lymphocyte ratio (NLR) has recently been reported to be a poor prognostic indicator in lung cancer. However, the prognostic value of the NLR in patients with lung cancer still remains controversial. We performed a meta-analysis to evaluate the prognostic value of NLR in patients with lung cancer. METHODS: We performed a comprehensive literature search in PubMed, Ovid, the Cochrane Library, and Web of Science databases in May 2015. Studies were assessed for quality using the Newcastle–Ottawa Scale. RESULTS: Twenty-two studies with a total of 7,054 patients were included in this meta-analysis. The meta-analysis was performed to generate combined hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS). Our analysis results indicated that high NLR predicted poorer OS (HR, 1.51; 95% confidence interval [CI], 1.33–1.71; P<0.001) and PFS (HR, 1.33; 95% CI, 1.07–1.67; P=0.012) in patients with lung cancer. High NLR was also associated with poor OS in lung cancer treated by surgical resection (HR, 1.59; 95% CI, 1.26–1.99; P<0.001) and chemotherapy (HR, 1.15; 95% CI, 1.08–1.22; P<0.001). In addition, NLR cut-off value =5 (HR, 1.57; 95% CI, 1.16–2.12; P=0.003) and NLR cut-off value <5 (HR, 1.47; 95% CI, 1.28–1.69; P<0.001). CONCLUSION: This meta-analysis result suggested that NLR should have significant predictive ability for estimating OS and PFS in patients with lung cancer and may be as a significant biomarker in the prognosis of lung cancer. Dove Medical Press 2015-09-29 /pmc/articles/PMC4599071/ /pubmed/26491346 http://dx.doi.org/10.2147/OTT.S90875 Text en © 2015 Zhao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhao, Qing-Tao Yang, Yong Xu, Shun Zhang, Xiao-Peng Wang, Hui-En Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
title | Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
title_full | Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
title_fullStr | Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
title_full_unstemmed | Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
title_short | Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
title_sort | prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599071/ https://www.ncbi.nlm.nih.gov/pubmed/26491346 http://dx.doi.org/10.2147/OTT.S90875 |
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