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Hypoxic Niche-Mediated Regeneration of Hematopoiesis in the Engraftment Window Is Dominantly Affected by Oxygen Tension in the Milieu

The bone marrow (BM) microenvironment or the hematopoietic stem cell (HSC) niche is normally hypoxic, which maintains HSC quiescence. Paradoxically, transplanted HSCs rapidly proliferate in this niche. Pretransplant myelosuppression results in a substantial rise in oxygen levels in the marrow microe...

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Detalles Bibliográficos
Autores principales:	Moirangthem, Ranjita Devi, Singh, Shweta, Adsul, Ashwini, Jalnapurkar, Sapana, Limaye, Lalita, Kale, Vaijayanti P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2015
Materias:	Original Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599134/ https://www.ncbi.nlm.nih.gov/pubmed/26107807 http://dx.doi.org/10.1089/scd.2015.0112

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