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Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study
OBJECTIVE: Venous thromboembolism (VTE) may be a marker of occult cancer in the general population. While liver disease is known to increase the risk of VTE and cancer, it is unclear whether VTE in patients with liver disease is also a marker of occult cancer. DESIGN: A population-based cohort study...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599159/ https://www.ncbi.nlm.nih.gov/pubmed/26462285 http://dx.doi.org/10.1136/bmjgast-2015-000043 |
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author | Montomoli, Jonathan Erichsen, Rune Søgaard, Kirstine Kobberøe Körmendiné Farkas, Dóra Bloch Münster, Anna-Marie Sørensen, Henrik Toft |
author_facet | Montomoli, Jonathan Erichsen, Rune Søgaard, Kirstine Kobberøe Körmendiné Farkas, Dóra Bloch Münster, Anna-Marie Sørensen, Henrik Toft |
author_sort | Montomoli, Jonathan |
collection | PubMed |
description | OBJECTIVE: Venous thromboembolism (VTE) may be a marker of occult cancer in the general population. While liver disease is known to increase the risk of VTE and cancer, it is unclear whether VTE in patients with liver disease is also a marker of occult cancer. DESIGN: A population-based cohort study. SETTING: Denmark. PARTICIPANTS: We used population-based health registries to identify all patients with liver disease in Denmark with a first-time diagnosis of VTE (including superficial or deep venous thrombosis and pulmonary embolism) during 1980–2010. Patients with non-cirrhotic liver disease and patients with liver cirrhosis were followed as two separate cohorts from the date of their VTE. MEASURES: For each cohort, we computed the absolute and relative risk (standardised incidence ratio; SIR) of cancer after VTE. RESULTS: During the study period, 1867 patients with non-cirrhotic liver disease and 888 with liver cirrhosis were diagnosed with incident VTE. In the first year following VTE, the absolute risk of cancer was 2.7% among patients with non-cirrhotic liver disease and 4.3% among those with liver cirrhosis. The SIR for the first 90 days of follow-up was 9.96 (95% CI 6.85 to 13.99) among patients with non-cirrhotic liver disease and 13.11 (95% CI 8.31 to 19.67) among patients with liver cirrhosis. After 1 year of follow-up, SIRs declined, but remained elevated in patients with non-cirrhotic liver disease (SIR=1.50, 95% CI 1.23 to 1.81) and patients with liver cirrhosis (SIR=1.95, 95% CI 1.45 to 2.57). CONCLUSIONS: VTE may be a marker of occult cancer in patients with liver disease. |
format | Online Article Text |
id | pubmed-4599159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45991592015-10-12 Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study Montomoli, Jonathan Erichsen, Rune Søgaard, Kirstine Kobberøe Körmendiné Farkas, Dóra Bloch Münster, Anna-Marie Sørensen, Henrik Toft BMJ Open Gastroenterol Cancer OBJECTIVE: Venous thromboembolism (VTE) may be a marker of occult cancer in the general population. While liver disease is known to increase the risk of VTE and cancer, it is unclear whether VTE in patients with liver disease is also a marker of occult cancer. DESIGN: A population-based cohort study. SETTING: Denmark. PARTICIPANTS: We used population-based health registries to identify all patients with liver disease in Denmark with a first-time diagnosis of VTE (including superficial or deep venous thrombosis and pulmonary embolism) during 1980–2010. Patients with non-cirrhotic liver disease and patients with liver cirrhosis were followed as two separate cohorts from the date of their VTE. MEASURES: For each cohort, we computed the absolute and relative risk (standardised incidence ratio; SIR) of cancer after VTE. RESULTS: During the study period, 1867 patients with non-cirrhotic liver disease and 888 with liver cirrhosis were diagnosed with incident VTE. In the first year following VTE, the absolute risk of cancer was 2.7% among patients with non-cirrhotic liver disease and 4.3% among those with liver cirrhosis. The SIR for the first 90 days of follow-up was 9.96 (95% CI 6.85 to 13.99) among patients with non-cirrhotic liver disease and 13.11 (95% CI 8.31 to 19.67) among patients with liver cirrhosis. After 1 year of follow-up, SIRs declined, but remained elevated in patients with non-cirrhotic liver disease (SIR=1.50, 95% CI 1.23 to 1.81) and patients with liver cirrhosis (SIR=1.95, 95% CI 1.45 to 2.57). CONCLUSIONS: VTE may be a marker of occult cancer in patients with liver disease. BMJ Publishing Group 2015-06-18 /pmc/articles/PMC4599159/ /pubmed/26462285 http://dx.doi.org/10.1136/bmjgast-2015-000043 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Cancer Montomoli, Jonathan Erichsen, Rune Søgaard, Kirstine Kobberøe Körmendiné Farkas, Dóra Bloch Münster, Anna-Marie Sørensen, Henrik Toft Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
title | Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
title_full | Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
title_fullStr | Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
title_full_unstemmed | Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
title_short | Venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
title_sort | venous thromboembolism and subsequent risk of cancer in patients with liver disease: a population-based cohort study |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599159/ https://www.ncbi.nlm.nih.gov/pubmed/26462285 http://dx.doi.org/10.1136/bmjgast-2015-000043 |
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